Abstract
The hemolytic activity of new spatially hindered hybrid antioxidants—Ichphans—has been studied. The concentration-dependent hemolytic action of high concentrations of Ichphans with 8, 10, 12, or 16 carbon atoms in the aliphatic chain has been revealed. A nonmonotonic dependence of the hemolytic activity on the hydrophobic properties of Ichphans has been found.
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G. A. Nikiforov, I. S. Belostotskaya, V. B. Vol’eva, et al., in Nauchn. Vestnik Tyumen. Med. Akad., Spets. Vypusk “Biooksidanty” (2003), pp. 50–51.
F. I. Braginskaya, E. M. Molochkina, O. M. Zorina, et al., in Alzheimer Disease: From Molecular Biology to Therapy, Ed. by R. Becker and E. Giacobini (Birkhauser-Boston, 1996), pp. 337–342.
E. M. Molotchkina, I. B. Ozerova, and E. B. Burlakova, Free Rad. Biol. Med. 33,2S1 (610), S229 (2002).
I. B. Ozerova, Candidate’s Dissertation in Biology (Emanuel Inst. Biochem. Phys., Moscow, 2000).
E. Yu. Parshina, L. Ya. Gendel, and A. B. Rubin, Biofizika 49(6), 1094 (2004).
E. Yu. Parshina, L. Ya. Gendel, and A. B. Rubin, Biofizika 50(4), 676 (2005).
E. Yu. Parshina, L. Ya. Gendel, and A. B. Rubin, Izv. RAN Ser. Biol., no. 6, 645 (2007).
B. Isomaa, H. Hagerstrand, G. Paatero, and A. C. Engblom, Biochim. Biophys. Acta 860(3), 510 (1986).
H. Kleszczynska, J. Sarapuk, and B. Rozycka-Roszak, Cell. Mol. Biol. Lett. 5(1), 67 (2000).
T. Fujiwara, N. Hirashima, S. Hasegawa, et al., Bioorg. Med. Chem. 9(4), 1013 (2001).
K. Miyajima, T. Baba, and M. Nakagaki, Colloid Polymer Sci., no. 265, 943 (1987).
M. Ohnishi and H. Sagitani, J. Am. Oil. Chem. Soc. 70(7), 679 (1993).
N. M. Storozhok, M. G. Perevozkina, A. G. Nikiforov, and I. F. Rusina, Nauchn. Vestnik Tyumen. Med. Akad., Spets. Vypusk “Biooksidanty” (2003), pp. 52–59.
V. V. Rozin, Ann. N.Y. Acad. Sci., no. 1048, 451 (2005).
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Original Russian Text © E.Yu. Parshina, L.Ya. Gendel, A.B. Rubin, 2009, published in Biofizika, 2009, Vol. 54, No. 6, pp. 1051–1054.
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Parshina, E.Y., Gendel, L.Y. & Rubin, A.B. Hemolytic activity of hybrid antioxidants Ichphans. BIOPHYSICS 54, 706–708 (2009). https://doi.org/10.1134/S0006350909060098
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DOI: https://doi.org/10.1134/S0006350909060098