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Does collagen microunfolding stimulate fibril formation?

  • Molecular Biophysics
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Abstract

The data on the effect of temperature on the kinetics of collagen fibril formation at physiological pH values and ionic strength in the temperature range 26–39°C have been analyzed. The temperature of 35°C optimal for collagen fibril formation has been defined as the point of inflection for half-maximal turbidity and collagen molecule microunfolding values, which corresponds to the temperature of the first transition on the heat absorption curve. The temperature range (32–35°C) in which collagen microunfolding stimulates fibril formation has been determined.

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Original Russian Text © T.I. Nikolaeva, S.M. Kuznetsova, E.I. Tiktopulo, 2009, published in Biofizika, 2009, Vol. 54, No. 6, pp. 1015–1018.

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Nikolaeva, T.I., Kuznetsova, S.M. & Tiktopulo, E.I. Does collagen microunfolding stimulate fibril formation?. BIOPHYSICS 54, 683–685 (2009). https://doi.org/10.1134/S0006350909060049

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  • DOI: https://doi.org/10.1134/S0006350909060049

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