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Relationship of the maximum QRS vector with the left ventricular myocardial mass during the development of hypertrophy: Computer simulation and empirical data

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Abstract

A model of electrical activity of the heart has been used to demonstrate that, all other conditions remaining the same, the spatial vector of the heart changes, as a first approximation, proportionally to the increase in the surface area of the heart ventricles (rather than the myocardial mass) during proportional homothetic changes in the sizes of the heart and His-Purkinje system. In contrast, the electrocardiosignal (ECS) amplitude is determined, at any given moment, by the area of depolarized regions of the epicardium and endocardium, which agrees with the model of a double electrical layer on the surface of an electrically active myocardium.

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Abbreviations

AH:

arterial hypertension

LVH:

left ventricular hypertrophy

ECG:

electrocardiogram

EchoCG:

echocardiogram

LVM:

left ventricle mass

LVMI:

left ventricle mass index

LV:

left ventricle

BP:

blood pressure

RV:

right ventricle

PWT:

LV posterior wall thickness

IVST:

interventricular septal thickness

EDD:

LV end diastolic dimension

BSA:

body surface area

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    O. V. Baum, V. I. Voloshin & L. A. Popov

  2. State Research Center of Prophylactic Medicine, Russian State Committee for Medical Technologies, Petroverigskii per. 10, Moscow, 101990, Russia

    G. A. Muromtseva

Authors
  1. O. V. Baum
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  2. V. I. Voloshin
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  3. L. A. Popov
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  4. G. A. Muromtseva
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Correspondence to O. V. Baum.

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Original Russian Text © O.V. Baum, V.I. Voloshin, L.A. Popov, G.A. Muromtseva, 2008, published in Biofizika, 2008, Vol. 53, No. 6, pp. 1109‐1124.

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Baum, O.V., Voloshin, V.I., Popov, L.A. et al. Relationship of the maximum QRS vector with the left ventricular myocardial mass during the development of hypertrophy: Computer simulation and empirical data. BIOPHYSICS 53, 632–644 (2008). https://doi.org/10.1134/S0006350908060304

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  • DOI: https://doi.org/10.1134/S0006350908060304

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