Abstract
An electophoretic study of changes in the content of intact titin isoforms, N2B-, N2BA-, N2A-titins and T2 in skeletal and cardiac muscles of ground squirrel (Spermophillus undulatus) is made in different periods: summer activity, autumnal activity, hibernation, arousal, and winter activity. In atria and ventricles of ground squirrels in the period of autumnal activity an increase (by ∼1.5 times) in the N2BA to N2B ratio was observed, in comparison with that in cardiac muscle in summer activity. During hibernation, the decrease in the relative content of N2B-, N2BA-titins and T2 in cardiac muscle as well as of N2A-titin and T2 in skeletal muscles was determined against the background of preservation of the relative amount of intact titin isoforms. At waking of ground squirrels and in a short period of winter activity, a rapid restoration of the content of N2B-, N2BA-, N2A-titisns and T2 in muscles was observed. In the myocardium of hibernating, waking ground squirrels and of those during winter activity the increased N2BA to N2B ratio was retained. The changes in the titin content are discussed in the aspect of adaptation of ground squirrels to hibernation.
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Original Russian Text © I.M. Vikhlyantsev, E.V. Karaduleva, Z.A. Podlubnaya, 2008, published in Biofizika, 2008, Vol. 53, No. 6, pp. 1066–1072.
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Vikhlyantsev, I.M., Karaduleva, E.V. & Podlubnaya, Z.A. Seasonal changes in the composition of titin isoforms in muscles of hibernating ground squirrels. BIOPHYSICS 53, 598–603 (2008). https://doi.org/10.1134/S0006350908060249
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DOI: https://doi.org/10.1134/S0006350908060249