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Oxygen effect in heat-induced DNA damage

  • Molecular Biophysics
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Abstract

The major kinds of heat-induced damage to DNA (depurination, guanine oxidation to 8-oxoguanine, cytosine deamination to uracil) were shown to depend in their extent on the oxygen content in solution. Formation of hydrogen peroxide in water upon heating was enhanced in the presence of D2O and decreased by various scavengers of singlet oxygen, corroborating the involvement of 1O2 in the thermal generation of reactive oxygen species. The aggregate data indicate that all kinds of heat-induced DNA damage in solution arise through this common mechanism.

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Abbreviations

OG:

7,8-dihydro-8-oxoguanine

ROS:

reactive oxygen species

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Authors and Affiliations

  1. Institute of Theoretica and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    A. V. Chernikov, S. V. Gudkov, I. N. Shtarkman & V. I. Bruskov

  2. Pushchino State University, Pushchino, Moscow Region, 142290, Russia

    I. N. Shtarkman & V. I. Bruskov

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  1. A. V. Chernikov
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  2. S. V. Gudkov
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  3. I. N. Shtarkman
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  4. V. I. Bruskov
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Additional information

Original Russian Text © A.V. Chemikov, S.V. Gudkov, I.N. Shtarkman, V.I. Bruskov, 2007, published in Biofizika, 2007, Vol. 52, No. 2, pp. 244–251.

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Chernikov, A.V., Gudkov, S.V., Shtarkman, I.N. et al. Oxygen effect in heat-induced DNA damage. BIOPHYSICS 52, 185–190 (2007). https://doi.org/10.1134/S0006350907020078

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  • DOI: https://doi.org/10.1134/S0006350907020078

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