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Biophysics

, Volume 52, Issue 1, pp 1–7 | Cite as

A comparative spin trapping study of the interaction of hypobromous and hypochlorous acids with tert-butyl hydroperoxide

  • A. V. Chekanov
  • A. N. Osipov
  • Yu. A. Vladimirov
  • V. I. Sergienko
  • O. M. Panasenko
Molecular Biophysics

Abstract

Hypochlorite (HOCl/OCl) and hypobromite (HOBr/OBr) are shown to react with tert-butyl hydroperoxide with close rate constants (10.8 and 8.9 M−1 s−1, respectively). Using a spin trap α-(4-pyridyl-1-oxide)-N-tert-butyl nitrone, both reactions are shown to proceed through decomposition of the hydroperoxide yielding butylperoxyl [˙OOC(CH3)3] and butoxyl [˙OC(CH3)3] radicals in a ratio depending on the hydroperoxide concentration. Thus, like hypochlorite, hypobromite can generate free radicals in reactions with organic hydroperoxides, which can be important for intensification of free-radical processes, e.g., lipid peroxidation at the chain branching stage.

Key words

hypochlorite hypobromite tert-butyl hydroperoxide free radicals peroxyl radical lipid peroxidation spin trap 

Abbreviations

MPO

myeloperoxidase

POBN

α-(4-pyridyl-1-oxide)-N-tert-butyl nitrone

TBHP

tert-butyl hydroperoxide

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Copyright information

© Pleiades Publishing, Inc. 2007

Authors and Affiliations

  • A. V. Chekanov
    • 1
  • A. N. Osipov
    • 2
  • Yu. A. Vladimirov
    • 2
  • V. I. Sergienko
    • 1
  • O. M. Panasenko
    • 1
  1. 1.Research Institute of Physico-Chemical MedicineMinistry of Health of the Russian FederationMoscowRussia
  2. 2.Russian State Medical UniversityMoscowRussia

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