Skip to main content
Log in

Dependence of dielectrophoretic force on the size of linear erythrocyte aggregates in suspension

  • Cell Biophysics
  • Published:
Biophysics Aims and scope Submit manuscript

Abstract

For modeling of erythrocyte rouleaux (linear cell aggregates) we develop an approximation procedure for the dipole moment in short cylinders, which contains the case of ellipsoidal bodies as a first approximation, but allows corrections for short cylinders, more representative for such particles. In dependence on the number of erythrocytes in an aggregation, i.e., on different but discrete rouleaux lengths, the dielectrophoretic force is calculated and represented against the frequency of the applied AC field. Predictions are made for frequency regions in the 107–108 Hz range where the magnitude and the direction of dielectrophoretic forces is different for different rouleaux sizes. This property can be used for the detection and spatial separation of rouleaux populations of different length in a microelectronic array.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. H. Morgan, M. P. Highes, and N. G. Green, Biophys. J. 77, 516 (1999).

    Google Scholar 

  2. M. P. Hughes, H. Morgan, F. J. Rixon, et al., Biochim. Biophys. Acta 1425, 119 (1998).

    Google Scholar 

  3. G. H. Markx, P. A. Dyda, and R. Pethig, J. Biotechnol. 51, 175 (1996).

    Article  Google Scholar 

  4. F. F. Becker, X. B. Wang, Y. Huang, et al., J. Phys. D Appl. Phys. 27, 2659 (1994).

    Article  ADS  Google Scholar 

  5. G. H. Markx and R. Pethig, Biotechnol. Bioeng. 45, 337 (1995).

    Article  Google Scholar 

  6. M. Talary, K. I. Mills, T. Hoy, et al., Med. Biol. Eng. Comp. 33, 235 (1995).

    Article  Google Scholar 

  7. N. G. Green and H. Morgan, J. Phys. D Appl. Phys. 30, 2626 (1997).

    Article  ADS  Google Scholar 

  8. X. B. Wang, J. Vykoukal, F. F. Becker, and P. R. C. Gascoyne, Biophys. J. 74, 2689 (1998).

    Google Scholar 

  9. C. L. Asbury and G. van den Engh, Biophys. J. 74, 1024 (1998).

    Google Scholar 

  10. M. Washizu, O. Kurosawa, L. Arai, et al., IEEE Trans. Ind. Appl. 31, 447 (1995).

    Article  Google Scholar 

  11. A. Ramos, H. Morgan, N. G. Green, and A. Castellanos, J. Phys. D Appl. Phys. 31, 2338 (1998).

    Article  ADS  Google Scholar 

  12. T. B. Jones, Electromechanics of particles (Cambridge University Press, Cambridge, 1995).

    Google Scholar 

  13. H. Morgan, N. G. Green, M. P. Huges, and T. C. Tan, J. Micromech. Microeng. 7, 65 (1997).

    Article  ADS  Google Scholar 

  14. M. S. Talary, J. P. H. Burt, J. A. Tame, and R. Pethig, J. Phys. D Appl. Phys. 29, 2198 (1996).

    Article  ADS  Google Scholar 

  15. R. D. Miller and T. B. Jones, Biophys. J. 64, 1588 (1993).

    Google Scholar 

  16. H. Morgan and N. G. Green, J. Electrostatics 42, 279 (1997).

    Article  Google Scholar 

  17. T. Chelidze, in Proceedings of First International Conference on Dielectrophoresis Spectrocopy in Physics, Chemistry and Boil. Appl. (DS 2001) (Jerusalem, 2001), p. 57.

  18. M. Baumann, Biophys. J. 77, 2602 (1999).

    Google Scholar 

  19. M. Krueger and F. Thorn, Biophys J. 73, 2653 (1997).

    Google Scholar 

  20. J. Voldman, R. A. Braff, M. Toner, et al., Biophys. J. 80, 531 (2001).

    Google Scholar 

  21. J. L. Sebastian, S. Muñioz, M. Sancho, and J. M. Miranda, Phys. Med. Biol. 46, 213 (2001).

    Article  Google Scholar 

  22. J. Stratton, in Electromagnetic Theory (McGraw-Hill, New York, 1941), pp. 513–573.

    MATH  Google Scholar 

  23. P. Bernardi, M. Cavagnaro, and L. M. D’Inzeo, in URSI XXVI General Assembly, Canada, 1999, p. 616.

  24. L. M. Liu and S. F. Cleary, Bioelectromagnetics. 16, 160 (1995).

    Article  Google Scholar 

  25. A. V. Priezzhev, N. N. Forsov, M. G. Vyshlova, et al., SPIE Proceedings 3599 (1999).

  26. J. Gimsa and D. Wachner, Biophys. J. 77, 1316 (1999).

    Article  Google Scholar 

  27. A. Bonincontro, J. Gimsa, G. Risuleo, and V. Rosa, Biol. Membrany 17, 102 (2000).

    Google Scholar 

  28. H. Pauly and H. P. Suwan, Biophys. J. 6, 621 (1966).

    Google Scholar 

  29. V. L. Kononenko and T. A. Ilyina, Membr. Cell. Biol. 14(4), 537 (2001).

    Google Scholar 

  30. P. Foresto, M. D’ Agrio, M. Carreras, et al., Medicina (B. Aires) 60, 570 (2000).

    Google Scholar 

  31. G. Bahrstein, D. Wajnblum, and S. Yedgar, Biophys. J. 78(5), 2470 (2000).

    Google Scholar 

  32. H. Baumler, B. Neu, E. Donath, and H. Kiesewetter, Biorheology 36(5–6), 439 (1999).

    Google Scholar 

  33. A. Irimajiri, M. Ando, R. Matsuoka, et al., Biochim. Biophys. Acta 1290(3), 207 (1996).

    Google Scholar 

  34. P. Riha, F. Liao, and J. F. Stoltz, Clin. Hemorheol. Microcirc. 17(4), 341 (1997).

    Google Scholar 

  35. S. Chien, L. A. Sung, S. Kim, et al., Microvasc. Res. 13(3), 327 (1977).

    Article  Google Scholar 

  36. L. Dintenfass, Adv. Space Res. 9(11), 65 (1989).

    Article  ADS  Google Scholar 

  37. H. Baumler, B. Neu, R. Mitlohner, et al., Biorheology 38(1), 39 (2001).

    Google Scholar 

  38. S. M. Bertoluzzo, A. Bollini, M. Rasia, and A. Raynal, Blood Cells Mol. Dis. 25(5–6), 339 (1999).

    Article  Google Scholar 

  39. A. Pribush, H. J. Meiselmann, D. Meyerstein, and N. Meyerstein, Biorheology 37(5–6), 429 (2000).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Original Russian Text © A. Zehe, A. Ramírez, O. Starostenko, 2006, published in Biofizika, 2006, Vol. 51, No. 4, pp. 724–732.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zehe, A., Ramírez, A. & Starostenko, O. Dependence of dielectrophoretic force on the size of linear erythrocyte aggregates in suspension. BIOPHYSICS 51, 645–653 (2006). https://doi.org/10.1134/S0006350906040208

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006350906040208

Key words

Navigation