Abstract
It is known that 5′-untranslated sequences of eukaryotic mRNA often contain AUG triplets, which can serve as translation initiation sites. It is assumed that such leader open reading frames can perform regulatory functions and code functionally active proteins; however, their characteristics have been studied insufficiently. In the article, the context organization of leader open reading frames of eukaryotic mRNA was considered. It was shown that their characteristics correlate with their position with respect to the protein-coding sequence, which may be related to the translation initiation efficiency.
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Abbreviations
- uAUG:
-
AUG codon contained in 5′-untranslated sequence (UTS)
- uORF:
-
open reading frame starting with uAUG
- CDS:
-
coding DNA sequence
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Original Russian Text © O.A. Volkova, A.V. Kochetov, S.E. Titov, N.A. Kolchanov, 2006, published in Biofizika, 2006, Vol. 51, No. 4, pp. 615–621.
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Volkova, O.A., Kochetov, A.V., Titov, S.E. et al. Potential open reading frames in 5′-untranslated regions of eukaryotic mRNA. BIOPHYSICS 51, 547–553 (2006). https://doi.org/10.1134/S0006350906040063
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DOI: https://doi.org/10.1134/S0006350906040063