Abstract
The presence of conserved telomeric repeats represented by the hexamer (TTAGGG)n at the chromosomal termini is necessary for the correct functioning and stability of chromosomes. A number of the genomes of mammals, including human, are known to contain interstitial telomeric sequences located far from the chromosomal termini. It is assumed that these repeats mark the regions of fusions or other rear-rangements of ancestral chromosomes. Exact localization of all interstitial telomeric sequences in the genome could significantly advance the understanding of the mechanisms of karyotype evolution and speciation. In this context, software was developed to search for degenerate interstitial telomeric repeats in complete sequences of mammalian chromosomes. The evolutionary significance of such repeats was demonstrated by the example of human chromosome 2. The results are available at http://www.bionet.nsc.ru/labs/theorylabmain/orlov/telomere/.
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Abbreviations
- ITS:
-
intrachromosomal telomeric sequences
References
J. Meyne, R. J. Baker, and H. H. Hobart, Chromosoma 99, 3 (1990).
H. Biessmann and J. M. Mason, Adv. Genet. 30, 185 (1992).
J. Meyne, R. L. Ratliff, and R. K. Moyis, Proc. Natl. Acad. Sci. USA 86, 7049 (1989).
C. Sena, B. P. Chowdhary, and I. Gustavsson, Hereditas 123(3), 269 (1995).
C. J. Metcalfe, M. D. Eldridge, L. R. McQuade, and P. G. Johnston, Cytogenet. Cell Genet. 78, 74 (1997).
J. W. Ijdo, A. Baldini, D. C. Ward, et al., Proc. Natl. Acad. Sci. USA 88, 9051 (1991).
A. S. Multani, M. Ozen, C. L. Furlong, et al., Chromosoma 110(3), 214 (2001).
C. M. Azzalin, E. Mucciolo, L. Bertoni, and E. Guilotto, Cytogenet. Cell Genet. 78, 112 (1997).
A. Ruiz-Herrera, M. Ponsa, F. Garcia, et al., Chromosome Res. 10, 33 (2002).
A. Ruiz-Herrera, F. Garcia, E. Guilotto, et al., Cytogenet. Genome Res. 108, 234 (2005).
C. M. Azzalin, S. G. Nergadze, and E. Guilotto, Chromosoma 110, 75 (2001).
S. G. Nergadze, M. Rocchi, C. M. Azzalin, et al., Genome Res. 14(9), 1704 (2004).
J. D. Thompson, D. G. Higgins, and T. J. Gibson, Nucl. Acids Res. 22, 4673 (1994).
G. Benson, Nucl. Acids Res. 27(2), 573 (1999).
Y. Fan, E. Linardopoulou, C. Friedman, et al., Genome Res. 12, 1651 (2002).
W. Murphy, D. Larkin, A. Everts-van der Wind, et al., Science 309, 613 (2005).
J. J. Yunis and O. Prakash, Science 215, 1525 (1982).
R. L. Stauffer, A. Walker, O. Ryder, et al., J. Hered. 92, 469 (2001).
F. Kasai, E. Takahashi, K. Koyama, et al., Chromosome Res. 8, 727 (2000).
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Original Russian Text © N.V. Vorob’eva, L.S. Biltueva, Yu.L. Orlov, A.S. Grafodatskii, N.A. Kolchanov, 2006, published in Biofizika, 2006, Vol. 51, No. 4, pp. 602–607.
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Vorob’eva, N.V., Biltueva, L.S., Orlov, Y.L. et al. Interstitial telomeric repeats as markers of evolutionary changes in the mammalian karyotype: Human chromosome 2. BIOPHYSICS 51, 535–540 (2006). https://doi.org/10.1134/S000635090604004X
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DOI: https://doi.org/10.1134/S000635090604004X