Abstract
A total of 790 Drosophila melanogaster genes that are alternatively spliced in a coding region and have orthologs in Drosophila pseudoobscura were studied. It proved that nucleotide substitutions are accumulated in alternative coding regions more rapidly than in constitutive coding regions. Moreover, the evolutionary patterns of alternative regions differing in insertion-deletion mechanisms (use of alternative promoters, splicing sites, or polyadenylation sites) differ significantly. The synonymous substitution rate in coding regions of genes varies more strongly than the nonsynonymous substitution rate. The patterns of substitutions in different classes of alternative regions of Drosophila melanogaster and mammals differ considerably.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. B. Malko, in Proceedings of the Second International Moscow Conference on Computational Molecular Biology, 2005, p. 224.
F. Clark and T. A. Thanaraj, Hum. Mol. Genet. 11, 451 (2001).
M. Burset, I. A. Seledtsov, and V. V. Solovyev, Nucl. Acids Res. 28, 4364 (2000).
R. Sorek and G. Ast, Genome Res. 13, 1631 (2003).
K. Iida and H. Akashi, Gene 261, 93 (2000).
E. O. Ermakova, in Proceedings of the Second International Moscow Conference on Computational Molecular Biology, 2005, p. 95.
M. Singer and P. Berg, Genes and Genomes: A Changing Perspective (University Science Books, Mill Valley, Calif., 1991; Mir, Moscow, 1998), Vol. 2.
A. A. Mironov, P. S. Novichkov, and M. S. Gelfand, Bioinformatics 17, 13 (2001).
Y. Ina, J. Mol. Evol. 40, 190 (1995).
M. Kimura, J. Mol. Evol. 16, 111 (1980).
L. Duret and D. Mouchiroud, Mol. Biol. Evol. 17, 68 (2000).
C. Pal, B. Papp, and L. D. Hurst, Genetics 158, 927 (2001).
Y. Xing and C. Lee, Proc. Natl. Acad. Sci. USA 102, 13526 (2005).
Author information
Authors and Affiliations
Additional information
Original Russian Text © E.O. Ermakova, D.B. Mal’ko, M.S. Gelfand, 2006, published in Biofizika, 2006, Vol. 51, No. 4, pp. 581–588.
Rights and permissions
About this article
Cite this article
Ermakova, E.O., Mal’ko, D.B. & Gelfand, M.S. Evolutionary differences between alternative and constitutive protein-coding regions of alternatively spliced genes of Drosophila . BIOPHYSICS 51, 515–522 (2006). https://doi.org/10.1134/S0006350906040014
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1134/S0006350906040014