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Presynaptic Plasticity Is Associated with Actin Polymerization

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Abstract

Modulation of presynaptic short-term plasticity induced by actin polymerization was studied in rat hippocampal slices using the paired-pulse paradigm. Schaffer collaterals were stimulated with paired pulses with a 70-ms interstimulus interval every 30 s before and during perfusion with jasplakinolide, an activator of actin polymerization. Jasplakinolide application resulted in the increase in the amplitudes of CA3-CA1 responses (potentiation) accompanied by a decrease in the paired-pulse facilitation, suggesting induction of presynaptic modifications. Jasplakinolide-induced potentiation depended on the initial paired-pulse rate. These data indicate that the jasplakinolide-mediated changes in actin polymerization increased the probability of neurotransmitter release. Less typical for CA3-CA1 synapses responses, such as a very low paired-pulse ratio (close to 1 or even lower) or even paired-pulse depression, were affected differently. Thus, jasplakinolide caused potentiation of the second, but not the first response to the paired stimulus, which increased the paired-pulse ratio from 0.8 to 1.0 on average, suggesting a negative impact of jasplakinolide on the mechanisms promoting paired-pulse depression. In general, actin polymerization facilitated potentiation, although the patterns of potentiation differed depending on the initial synapse characteristics. We conclude that in addition to the increase in the neurotransmitter release probability, jasplakinolide induced other actin polymerization-dependent mechanisms, including those involved in the paired-pulse depression.

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Abbreviations

LTP:

long-term potentiation

PPD:

paired-pulse depression

PPF:

paired-pulse facilitation

PPR:

paired-pulse ratio

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Funding

The work was supported by the State Assignment of the Ministry of Science and Higher Education of the Russian Federation for 2021-2023 (AAAA-A17-117092040002-6).

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  1. Laboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 119991, Moscow, Russia

    Irina Kudryashova

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Correspondence to Irina Kudryashova.

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The author declares no conflict of interest. The funding organization had no role in the study design, collection, analysis and interpretation of data, writing of the manuscript, and decision to publish the results. All experiments were conducted according to the guidelines of the Declaration of Helsinki, EU Directive 2010/63/EU on the protection of animals used for scientific purposes, and experimental protocols approved by the Ethics Committee of the Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences.

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Kudryashova, I. Presynaptic Plasticity Is Associated with Actin Polymerization. Biochemistry Moscow 88, 392–403 (2023). https://doi.org/10.1134/S0006297923030082

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