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Investigations of Photosensitive Proteins by Serial Crystallography

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Abstract

This review contains recent data on serial femtosecond X-ray crystallography (SFX), based on a femtosecond X-ray free electron laser, as well as on the possibilities of its application for studying photosensitive proteins. Development of this method began rather recently, and it has already shown its effectiveness and some unique advantages over conventional X-ray structural analysis. This technology is especially promising for structural studies of membrane proteins and for kinetic studies. The main principle of the method, the possibility of its application in structural biology, its advantages and disadvantages, as well as its prospects for further development are analyzed in this review. Special attention is given to publications in which the SFX method has been used to study photosensitive proteins.

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Abbreviations

LCP:

lipid cubic phase

LSP:

lipid sponge phase

PSI(II):

photosystem I(II)

PYP:

photoactive yellow protein

RC:

reaction center

SFX:

serial femtosecond X-ray analysis

XFEL:

X-ray free-electron laser

XRD:

X-ray diffraction analysis

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Authors and Affiliations

  1. Institute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia

    G. K. Selikhanov, M. S. Fando, M. V. Dontsova & A. G. Gabdulkhakov

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  1. G. K. Selikhanov
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  2. M. S. Fando
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  3. M. V. Dontsova
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  4. A. G. Gabdulkhakov
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Original Russian Text © G. K. Selikhanov, M. S. Fando, M. V. Dontsova, A. G. Gabdulkhakov, 2018, published in Uspekhi Biologicheskoi Khimii, 2018, Vol. 58, pp. 347–376.

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Selikhanov, G.K., Fando, M.S., Dontsova, M.V. et al. Investigations of Photosensitive Proteins by Serial Crystallography. Biochemistry Moscow 83 (Suppl 1), S163–S175 (2018). https://doi.org/10.1134/S0006297918140134

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