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Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients

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Abstract

Abzymes with various catalytic activities are the earliest statistically significant markers of existing and developing autoimmune diseases (AIDs). Currently, schizophrenia (SCZD) is not considered to be a typical AID. It was demonstrated recently that antibodies from SCZD patients efficiently hydrolyze DNA and myelin basic protein. Here, we showed for the first time that autoantibodies from 35 SCZD patients efficiently hydrolyze RNA (cCMP > poly(C) > poly(A) > yeast RNA) and analyzed site-specific hydrolysis of microRNAs involved in the regulation of several genes in SCZD (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p). All four microRNAs were cleaved by IgG preparations (n = 21) from SCZD patients in a site-specific manner. The RNase activity of the abzymes correlated with SCZD clinical parameters. The data obtained showed that SCZD patients might display signs of typical autoimmune processes associated with impaired functioning of microRNAs resulting from their hydrolysis by the abzymes.

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Abbreviations

AID:

autoimmune disease

CC:

correlation coefficient

MBP:

myelin basic protein

MS:

multiple sclerosis

SLE:

systemic lupus erythematosus

SCZD:

schizophrenia

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia

    E. A. Ermakov, V. N. Buneva & G. A. Nevinsky

  2. Novosibirsk State University, 630090, Novosibirsk, Russia

    E. A. Ermakov, V. N. Buneva & G. A. Nevinsky

  3. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014, Tomsk, Russia

    S. A. Ivanova

Authors
  1. E. A. Ermakov
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  2. S. A. Ivanova
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  3. V. N. Buneva
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  4. G. A. Nevinsky
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Correspondence to G. A. Nevinsky.

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Original Russian Text © E. A. Ermakov, S. A. Ivanova, V. N. Buneva, G. A. Nevinsky, 2018, published in Biokhimiya, 2018, Vol. 83, No. 5, pp. 673–694.

Originally published in Biochemistry (Moscow) On-Line Papers in Press, as Manuscript BM 17–417, March 26, 2018.

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Ermakov, E.A., Ivanova, S.A., Buneva, V.N. et al. Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients. Biochemistry Moscow 83, 507–526 (2018). https://doi.org/10.1134/S0006297918050048

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  • DOI: https://doi.org/10.1134/S0006297918050048

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