Biochemistry (Moscow)

, Volume 83, Issue 4, pp 359–369 | Cite as

Role of Nuclear Lamina in Gene Repression and Maintenance of Chromosome Architecture in the Nucleus

  • Y. Y. Shevelyov
  • S. V. Ulianov


Nuclear lamina is a protein meshwork composed of lamins and lamin-associated proteins that lines the nuclear envelope from the inside and forms repressive transcription compartment. The review presents current data on the contribution of nuclear lamina to the repression of genes located in this compartment and on the mechanisms of chromatin attachment to the nuclear envelope.


nuclear lamina lamina-associated domain nuclear envelope nuclear periphery repression 



DNA adenine methyltransferase identification


fluorescent in situ hybridization


lamina-associated domain


lamin B receptor


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia
  2. 2.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  3. 3.Lomonosov Moscow State UniversityFaculty of BiologyMoscowRussia

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