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PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer

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Abstract

Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PDX1 belongs to the family of master regulators with multiple and often antagonistic functions.

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Abbreviations

EMT:

epithelial–mesenchymal transition

PDAC:

pancreatic ductal adenocarcinoma

PDX1:

pancreatic and duodenal homeobox 1

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Authors and Affiliations

  1. Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    T. V. Vinogradova & E. D. Sverdlov

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  1. T. V. Vinogradova
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  2. E. D. Sverdlov
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Correspondence to T. V. Vinogradova.

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Original Russian Text © T. V. Vinogradova, E. D. Sverdlov, 2017, published in Biokhimiya, 2017, Vol. 82, No. 8, pp. 1154-1162.

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Vinogradova, T.V., Sverdlov, E.D. PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer. Biochemistry Moscow 82, 887–893 (2017). https://doi.org/10.1134/S000629791708003X

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  • DOI: https://doi.org/10.1134/S000629791708003X

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