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Formyl peptide receptor polymorphisms: 27 most possible ways for phagocyte dysfunction

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Abstract

Formyl peptide receptors (FPRs) expressed by mammalian myeloid cells are the important part of innate immunity. They belong to the seven-transmembrane domain class of receptors coupled to heterotrimeric GTP-binding proteins. Binding of the receptor with a wide spectrum of exogenous and endogenous ligands triggers such defensive phagocyte reactions as chemotaxis, secretory degranulation, and respiratory burst, keeping a balance of inflammatory and antiinflammatory processes in the organism. The association between single nucleotide polymorphisms in the gene of FPR1 receptor resulting in disruption of the receptor structure and the development of certain pathologies accompanied with inflammation, such as aggressive periodontitis, macular degeneration, and even gastric cancer (Maney, P., and Walters, J. D. (2009) J. Periodontol., 80, 1498-1505; Liang, X. Y., et al. (2014) Eye, 28, 1502-1510; Otani, T., et al. (2011) Biochem. Biophys. Res. Commun., 405, 356-361) has been shown. In this review, we matched the missense mutation of formyl-peptide receptors with their known functional domains and classified them according to their potential significance in pathology.

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Abbreviations

fMLF:

N-formyl-methionyl-leucyl-phenylalanine

FPR:

formyl peptide receptor

GPCR:

G-protein coupled receptor

SNP:

single nucleotide polymorphism

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Authors and Affiliations

  1. Kazan State Medical Academy, Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education”, Ministry of Healthcare of Russian Federation, 420012, Kazan, Russia

    S. S. Skvortsov & A. G. Gabdoulkhakova

  2. Kazan (Volga Region) Federal University, 420000, Kazan, Russia

    A. G. Gabdoulkhakova

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  1. S. S. Skvortsov
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Correspondence to A. G. Gabdoulkhakova.

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Published in Russian in Biokhimiya, 2017, Vol. 82, No. 4, pp. 587-600.

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Skvortsov, S.S., Gabdoulkhakova, A.G. Formyl peptide receptor polymorphisms: 27 most possible ways for phagocyte dysfunction. Biochemistry Moscow 82, 426–437 (2017). https://doi.org/10.1134/S0006297917040034

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