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On the paper by E. R. Muslikhov, I. F. Sukhanova, and P. V. Avdonin entitled “Arachidonic acid activates release of calcium ions from reticulum via ryanodine receptor channels in C2C12 skeletal myotubes” published in Biochemistry (Moscow), Vol. 79, No. 5, pp. 435–439 (2014)

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Abstract

A recent study published by Muslikhov et al. (Biochemistry (Moscow), 79, 435–439 (2014)) showed that arachidonic acid increases cytosolic Ca2+ concentrations in C2C12 skeletal myotubes mainly via activation of the ryanodine (RY) receptor 1. These results are consistent with the data from another study demonstrating that arachidonic acid targets RY receptor 2 in clonal and primary pancreatic β-cells (Woolcott et al., 2006). A novel and intriguing finding by Muslikhov’s group is that arachidonic acid also appears to activate the two-pore ion channel (TPC), suggesting that arachidonic acid could be a mediator in the interaction between TPCs and RY receptors.

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References

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Authors and Affiliations

  1. Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Thalians E102, Los Angeles, California, USA

    Orison O. Woolcott

  2. Department of Clinical Sciences and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

  3. Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden

    Md. Shahidul Islam

Authors
  1. Orison O. Woolcott
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  2. Md. Shahidul Islam
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Correspondence to Orison O. Woolcott.

Additional information

Published in Russian in Biokhimiya, 2014, Vol. 79, No. 8, pp. 1052–1053.

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Woolcott, O.O., Islam, M.S. On the paper by E. R. Muslikhov, I. F. Sukhanova, and P. V. Avdonin entitled “Arachidonic acid activates release of calcium ions from reticulum via ryanodine receptor channels in C2C12 skeletal myotubes” published in Biochemistry (Moscow), Vol. 79, No. 5, pp. 435–439 (2014). Biochemistry Moscow 79, 845–846 (2014). https://doi.org/10.1134/S0006297914080136

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  • DOI: https://doi.org/10.1134/S0006297914080136

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