Skip to main content

Malignant melanoma and melanocortin 1 receptor

Biochemistry (Moscow) volume 78, pages 1228–1237 (2013)Cite this article

Abstract

The conventional chemotherapeutic treatment of malignant melanoma still remains poorly efficient in most cases. Thus the use of specific features of these tumors for development of new therapeutic modalities is highly needed. Melanocortin 1 receptor (MC1R) overexpression on the cell surface of the vast majority of human melanomas, making MC1R a valuable marker of these tumors, is one of these features. Naturally, MC1R plays a key role in skin protection against damaging ultraviolet radiation by regulating eumelanin production. MC1R activation is involved in regulation of melanocyte cell division. This article reviews the peculiarities of regulation and expression of MC1R, melanocytes, and melanoma cells, along with the possible connection of MC1R with signaling pathways regulating proliferation of tumor cells. MC1R is a cell surface endocytic receptor, thus considered perspective for diagnostics and targeted drug delivery. A number of new therapeutic approaches that utilize MC1R, including endoradiotherapy with Auger electron and α- and β-particle emitters, photodynamic therapy, and gene therapy are now being developed.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Abbreviations

ACTH:

adrenocorticotropin

AGRP:

agouti-related protein

α-MSH:

α-melanocyte-stimulating hormone

ARRB1:

arrestin-beta-1

ARRB2:

arrestin-beta-2

ASIP:

agouti signal protein

Bcl-2:

apoptosis regulator from B-cell lymphoma 2

BD3:

β-defensin 3

BRAF:

v-Raf murine sarcoma viral oncogene homolog B1

CDKN2A:

cyclin-dependent kinase inhibitor 2A

CRE:

cAMP-responsive element

CREB:

cAMP-responsive element-binding protein

ERK:

extracellular signal-regulated kinases

GPCR:

G-protein coupled receptors

GRK:

GPCR kinase

I-κB:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

LET:

linear energy transfer

MAPK:

mitogen-activated protein kinases

MC1R:

melanocortin 1 receptor

MGRN1:

mahogunin RING finger-1 (ubiquitin E3 ligase with RING-domain)

MITF:

microphthalmia transcription factor

MRAP:

melanocortin-2-receptor accessory protein

mTor:

mammalian target of rapamycin

NEDD9:

neural precursor cell expressed, developmentally down-regulated 9

NF-κB:

nuclear factor kappa-light-chain-enhancer of activated B cells

NIS:

Na-I symporter

PKA:

protein kinase A

RING:

real interesting new gene

Sdc2:

syndecane-2

TUBB3:

β-III-tubulin

References

  1. Chissov, V. I., Starinsky, V. V., and Petrova, G. V. (eds.) Malignant Neoplasms in Russia in 2011 (Morbidity and Mortality), PA Herzen MNIOI Company, Ministry of Health of Russian Federation, Moscow.

  2. Siegel, R., Ward, E., Brawley, O., and Jemal, A. (2011) CA Cancer J. Clin., 61, 212–236.

    PubMed  Google Scholar 

  3. Al-Hilli, Z., Evoy, D., Geraghty, J. G., McDermott, E. W., and Prichard, R. S. (2013) in Melanoma — From Early Detection to Treatment (Duc, T. H., ed.) InTech, Rijeka, pp. 411–437.

  4. Lee, B., Mukhi, N., and Liu, D. (2012) J. Hematol. Oncol., 5, 1–7.

    Google Scholar 

  5. Balch, C. M., Gershenwald, J. E., Soong, S. J., Thompson, J. F., Atkins, M. B., Byrd, D. R., Buzaid, A. C., Cochran, A. J., Coit, D. G., Ding, S., Eggermont, A. M., Flaherty, K. T., Gimotty, P. A., Kirkwood, J. M., McMasters, K. M., Mihm, M. C., Jr., Morton, D. L., Ross, M. I., Sober, A. J., and Sondak, V. K. (2009) J. Clin. Oncol., 27, 6199–6206.

    PubMed  Google Scholar 

  6. Pleshkan, V. V., Zinov’eva, M. V., and Sverdlov, E. D. (2011) Mol. Biol. (Moscow), 45, 416–433.

    CAS  Google Scholar 

  7. Eggermont, A. M. (2010) Ann. Oncol., 21, vii339–vii344.

    PubMed  Google Scholar 

  8. Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., and Steketee, J. D. (2012) Adv. Anat. Embryol. Cell Biol., 212, v–115.

    PubMed  Google Scholar 

  9. Abdel-Malek, Z. A., Knittel, J., Kadekaro, A. L., Swope, V. B., and Starner, R. (2008) Photochem. Photobiol., 84, 501–508.

    PubMed  CAS  Google Scholar 

  10. Anisimov, V. V., and Vagner, R. I. (1995) Skin Melanoma. Part 1. Epidemiology, Etiology, Pathogenesis, Prevention [in Russian], Nauka, St. Petersburg.

    Google Scholar 

  11. Slominski, A., Wortsman, J., Carlson, A. J., Matsuoka, L. Y., Balch, C. M., and Mihm, M. C. (2001) Arch. Pathol. Lab Med., 125, 1295–1306.

    PubMed  CAS  Google Scholar 

  12. Wikberg, J. E., Muceniece, R., Mandrika, I., Prusis, P., Lindblom, J., Post, C., and Skottner, A. (2000) Pharmacol. Res., 42, 393–420.

    PubMed  CAS  Google Scholar 

  13. Ibrahim, N., and Haluska, F. G. (2009) Annu. Rev. Pathol., 4, 551–579.

    PubMed  CAS  Google Scholar 

  14. Kim, M., Gans, J. D., Nogueira, C., Wang, A., Paik, J. H., Feng, B., Brennan, C., Hahn, W. C., Cordon-Cardo, C., Wagner, S. N., Flotte, T. J., Duncan, L. M., Granter, S. R., and Chin, L. (2006) Cell, 125, 1269–1281.

    PubMed  CAS  Google Scholar 

  15. Moore, S. R., Persons, D. L., Sosman, J. A., Bobadilla, D., Bedell, V., Smith, D. D., Wolman, S. R., Tuthill, R. J., Moon, J., Sondak, V. K., and Slovak, M. L. (2008) Clin. Cancer Res., 14, 2927–2935.

    PubMed  CAS  Google Scholar 

  16. Tsao, H., Chin, L., Garraway, L. A., and Fisher, D. E. (2012) Genes Dev., 26, 1131–1155.

    PubMed  CAS  Google Scholar 

  17. Jang, S., and Atkins, M. B. (2013) Lancet Oncol., 14, e60–e69.

    PubMed  CAS  Google Scholar 

  18. Eberle, A. N. (1981) Biochem. Soc. Trans., 9, 37–39.

    PubMed  CAS  Google Scholar 

  19. Tatro, J. B., Atkins, M., Mier, J. W., Hardarson, S., Wolfe, H., Smith, T., Entwistle, M. L., and Reichlin, S. (1990) J. Clin. Invest., 85, 1825–1832.

    PubMed  CAS  Google Scholar 

  20. Tatro, J. B., Wen, Z., Entwistle, M. L., Atkins, M. B., Smith, T. J., Reichlin, S., and Murphy, J. R. (1992) Cancer Res., 52, 2545–2548.

    PubMed  CAS  Google Scholar 

  21. Funasaka, Y., Sato, H., Chakraborty, A. K., Ohashi, A., Chrousos, G. P., and Ichihashi, M. (1999) J. Investig. Dermatol. Symp. Proc., 4, 105–109.

    PubMed  CAS  Google Scholar 

  22. Loir, B., Perez, S. C., Ghanem, G., Lozano, J. A., Garcia-Borron, J. C., and Jimenez-Cervantes, C. (1999) Cell Mol. Biol. (Noisy-le-Grand), 45, 1083–1092.

    CAS  Google Scholar 

  23. Salazar-Onfray, F., Lopez, M., Lundqvist, A., Aguirre, A., Escobar, A., Serrano, A., Korenblit, C., Petersson, M., Chhajlani, V., Larsson, O., and Kiessling, R. (2002) Br. J. Cancer, 87, 414–422.

    PubMed  CAS  Google Scholar 

  24. Lopez, M. N., Pereda, C., Ramirez, M., Mendoza-Naranjo, A., Serrano, A., Ferreira, A., Poblete, R., Kalergis, A. M., Kiessling, R., and Salazar-Onfray, F. (2007) Invest. Ophthalmol. Vis. Sci., 48, 1219–1227.

    PubMed  Google Scholar 

  25. Ogbah, Z., Puig-Butille, J. A., Simonetta, F., Badenas, C., Cervera, R., Mila, J., Benitez, D., Malvehy, J., Vilella, R., and Puig, S. (2012) Anticancer Res., 32, 1245–1251.

    PubMed  CAS  Google Scholar 

  26. Halaban, R. (2000) Pigment Cell Res., 13, 4–14.

    PubMed  CAS  Google Scholar 

  27. Muffley, L. A., Zhu, K. Q., Engrav, L. H., Gibran, N. S., and Hocking, A. M. (2011) J. Histochem. Cytochem., 59, 278–288.

    PubMed  CAS  Google Scholar 

  28. Eves, P. C., and Haycock, J. W. (2010) Adv. Exp. Med. Biol., 681, 19–28.

    PubMed  CAS  Google Scholar 

  29. Scherer, D., and Kumar, R. (2010) Mutat. Res., 705, 141–153.

    PubMed  CAS  Google Scholar 

  30. Li, G., and Herlyn, M. (2000) Mol. Med. Today, 6, 163–169.

    PubMed  CAS  Google Scholar 

  31. Chakraborty, A. K., Funasaka, Y., Slominski, A., Ermak, G., Hwang, J., Pawelek, J. M., and Ichihashi, M. (1996) Biochim. Biophys. Acta, 1313, 130–138.

    PubMed  Google Scholar 

  32. Chakraborty, A. K., Funasaka, Y., Pawelek, J. M., Nagahama, M., Ito, A., and Ichihashi, M. (1999) J. Invest. Dermatol., 112, 853–860.

    PubMed  CAS  Google Scholar 

  33. D’Orazio, J. A., Nobuhisa, T., Cui, R., Arya, M., Spry, M., Wakamatsu, K., Igras, V., Kunisada, T., Granter, S. R., Nishimura, E. K., Ito, S., and Fisher, D. E. (2006) Nature, 443, 340–344.

    PubMed  Google Scholar 

  34. Tada, A., Suzuki, I., Im, S., Davis, M. B., Cornelius, J., Babcock, G., Nordlund, J. J., and Abdel-Malek, Z. A. (1998) Cell Growth Differ., 9, 575–584.

    PubMed  CAS  Google Scholar 

  35. Scott, M. C., Suzuki, I., and Abdel-Malek, Z. A. (2002) Pigment Cell Res., 15, 433–439.

    PubMed  CAS  Google Scholar 

  36. Suzuki, I., Cone, R. D., Im, S., Nordlund, J., and Abdel-Malek, Z. A. (1996) Endocrinology, 137, 1627–1633.

    PubMed  CAS  Google Scholar 

  37. Rouzaud, F., Annereau, J. P., Valencia, J. C., Costin, G. E., and Hearing, V. J. (2003) FASEB J., 17, 2154–2156.

    PubMed  CAS  Google Scholar 

  38. Rouzaud, F., Kadekaro, A. L., Abdel-Malek, Z. A., and Hearing, V. J. (2005) Mutat. Res., 571, 133–152.

    PubMed  CAS  Google Scholar 

  39. Siegrist, W., Stutz, S., and Eberle, A. N. (1994) Cancer Res., 54, 2604–2610.

    PubMed  CAS  Google Scholar 

  40. Xia, Y., Skoog, V., Muceniece, R., Chhajlani, V., and Wikberg, J. E. (1995) Eur. J. Pharmacol., 288, 277–283.

    PubMed  CAS  Google Scholar 

  41. Mandrika, I., Petrovska, R., and Wikberg, J. (2005) Biochem. Biophys. Res. Commun., 326, 349–354.

    PubMed  CAS  Google Scholar 

  42. Zanna, P. T., Sanchez-Laorden, B. L., Perez-Oliva, A. B., Turpin, M. C., Herraiz, C., Jimenez-Cervantes, C., and Garcia-Borron, J. C. (2008) Biochem. Biophys. Res. Commun., 368, 211–216.

    PubMed  CAS  Google Scholar 

  43. Beaumont, K. A., Liu, Y. Y., and Sturm, R. A. (2009) Prog. Mol. Biol. Transl. Sci., 88, 85–153.

    PubMed  CAS  Google Scholar 

  44. Wong, W., and Minchin, R. F. (1996) Int. J. Biochem. Cell Biol., 28, 1223–1232.

    PubMed  CAS  Google Scholar 

  45. Sanchez-Mas, J., Guillo, L. A., Zanna, P., Jimenez-Cervantes, C., and Garcia-Borron, J. C. (2005) Mol. Endocrinol., 19, 1035–1048.

    PubMed  CAS  Google Scholar 

  46. Sanchez-Laorden, B. L., Jimenez-Cervantes, C., and Garcia-Borron, J. C. (2007) J. Biol. Chem., 282, 3241–3251.

    PubMed  CAS  Google Scholar 

  47. Abrisqueta, M., Herraiz, C., Perez Oliva, A. B., Sanchez-Laorden, B. L., Olivares, C., Jimenez-Cervantes, C., and Garcia-Borron, J. C. (2013) J. Cell Sci., jcs.128322; Advance Online Article June 7, 2013.

    Google Scholar 

  48. Xia, Y., Muceniece, R., and Wikberg, J. E. (1996) Cancer Lett., 98, 157–162.

    PubMed  CAS  Google Scholar 

  49. Thornwall, M., Dimitriou, A., Xu, X., Larsson, E., and Chhajlani, V. (1997) Horm. Res., 48, 215–218.

    PubMed  CAS  Google Scholar 

  50. Chan, L. F., Webb, T. R., Chung, T. T., Meimaridou, E., Cooray, S. N., Guasti, L., Chapple, J. P., Egertova, M., Elphick, M. R., Cheetham, M. E., Metherell, L. A., and Clark, A. J. (2009) Proc. Natl. Acad. Sci. USA, 106, 6146–6151.

    PubMed  CAS  Google Scholar 

  51. He, L., Gunn, T. M., Bouley, D. M., Lu, X. Y., Watson, S. J., Schlossman, S. F., Duke-Cohan, J. S., and Barsh, G. S. (2001) Nat. Genet., 27, 40–47.

    PubMed  CAS  Google Scholar 

  52. Perez-Oliva, A. B., Olivares, C., Jimenez-Cervantes, C., and Garcia-Borron, J. C. (2009) J. Biol. Chem., 284, 31714–31725.

    PubMed  CAS  Google Scholar 

  53. Eberle, A. N., Siegrist, W., Bagutti, C., Chluba-De Tapia, J., Solca, F., Wikberg, J. E., and Chhajlani, V. (1993) Ann. N. Y. Acad. Sci., 680, 320–341.

    PubMed  CAS  Google Scholar 

  54. Garcia-Borron, J. C., Sanchez-Laorden, B. L., and Jimenez-Cervantes, C. (2005) Pigment Cell Res., 18, 393–410.

    PubMed  CAS  Google Scholar 

  55. Peters, E. M., Tobin, D. J., Seidah, N. G., and Schallreuter, K. U. (2000) J. Invest. Dermatol., 114, 430–437.

    PubMed  CAS  Google Scholar 

  56. Dalziel, M., Kolesnichenko, M., das Neves, R. P., Iborra, F., Goding, C., and Furger, A. (2011) Nucleic Acids Res., 39, 2378–2392.

    PubMed  CAS  Google Scholar 

  57. Ramachandrappa, S., Gorrigan, R. J., Clark, A. J., and Chan, L. F. (2013) Front. Endocrinol. (Lausanne), 4, 9.

    CAS  Google Scholar 

  58. Bohm, M., Metze, D., Schulte, U., Becher, E., Luger, T. A., and Brzoska, T. (1999) Exp. Dermatol., 8, 453–461.

    PubMed  CAS  Google Scholar 

  59. Wikberg, J. E. (1999) Eur. J. Pharmacol., 375, 295–310.

    PubMed  CAS  Google Scholar 

  60. Hartmeyer, M., Scholzen, T., Becher, E., Bhardwaj, R. S., Schwarz, T., and Luger, T. A. (1997) J. Immunol., 159, 1930–1937.

    PubMed  CAS  Google Scholar 

  61. Luger, T. A., Scholzen, T. E., Brzoska, T., and Bohm, M. (2003) Ann. N. Y. Acad. Sci., 994, 133–140.

    PubMed  CAS  Google Scholar 

  62. Roberts, D. W., Newton, R. A., Beaumont, K. A., Helen, L. J., and Sturm, R. A. (2006) Pigment Cell Res., 19, 76–89.

    PubMed  CAS  Google Scholar 

  63. Sturm, R. A. (2009) Hum. Mol. Genet., 18, R9–17.

    Google Scholar 

  64. Ibrahim, N., and Haluska, F. G. (2009) Annu. Rev. Pathol., 4, 551–579.

    PubMed  CAS  Google Scholar 

  65. Demenais, F., Mohamdi, H., Chaudru, V., Goldstein, A. M., Newton Bishop, J. A., Bishop, D. T., Kanetsky, P. A., Hayward, N. K., Gillanders, E., Elder, D. E., Avril, M. F., Azizi, E., van Belle, P., Bergman, W., Bianchi-Scarra, G., Bressac-de Paillerets, B., Calista, D., Carrera, C., Hansson, J., Harland, M., Hogg, D., Hoiom, V., Holland, E. A., Ingvar, C., Landi, M. T., Lang, J. M., Mackie, R. M., Mann, G. J., Ming, M. E., Njauw, C. J., Olsson, H., Palmer, J., Pastorino, L., Puig, S., Randerson-Moor, J., Stark, M., Tsao, H., Tucker, M. A., van der Velden, P., Yang, X. R., and Gruis, N. (2010) J. Natl. Cancer Inst., 102, 1568–1583.

    PubMed  CAS  Google Scholar 

  66. Beaumont, K. A., Wong, S. S., Ainger, S. A., Liu, Y. Y., Patel, M. P., Millhauser, G. L., Smith, J. J., Alewood, P. F., Leonard, J. H., and Sturm, R. A. (2011) Eur. J. Pharmacol., 660, 103–110.

    PubMed  CAS  Google Scholar 

  67. Chung, H., Lee, J. H., Jeong, D., Han, I. O., and Oh, E. S. (2012) J. Biol. Chem., 287, 19326–19335.

    PubMed  CAS  Google Scholar 

  68. Flaherty, K. T., Hodi, F. S., and Fisher, D. E. (2012) Nat. Rev. Cancer, 12, 349–361.

    PubMed  CAS  Google Scholar 

  69. Herraiz, C., Journe, F., Abdel-Malek, Z., Ghanem, G., Jimenez-Cervantes, C., and Garcia-Borron, J. C. (2011) Mol. Endocrinol., 25, 138–156.

    PubMed  CAS  Google Scholar 

  70. Herraiz, C., Jimenez-Cervantes, C., Zanna, P., and Garcia-Borron, J. C. (2009) FEBS Lett., 583, 3269–3274.

    PubMed  CAS  Google Scholar 

  71. Herraiz, C., Journe, F., Ghanem, G., Jimenez-Cervantes, C., and Garcia-Borron, J. C. (2012) Int. J. Biochem. Cell Biol., 44, 2244–2252.

    PubMed  CAS  Google Scholar 

  72. Abdel-Malek, Z. A. (2001) Cell Mol. Life Sci., 58, 434–441.

    PubMed  CAS  Google Scholar 

  73. Wikberg, J. E., Muceniece, R., Mandrika, I., Prusis, P., Lindblom, J., Post, C., and Skottner, A. (2000) Pharmacol. Res., 42, 393–420.

    PubMed  CAS  Google Scholar 

  74. Bousquet, C., and Melmed, S. (1999) J. Biol. Chem., 274, 10723–10730.

    PubMed  CAS  Google Scholar 

  75. Voisey, J., and Van Daal, A. (2002) Pigment Cell Res., 15, 10–18.

    PubMed  CAS  Google Scholar 

  76. Swope, V. B., Jameson, J. A., McFarland, K. L., Supp, D. M., Miller, W. E., McGraw, D. W., Patel, M. A., Nix, M. A., Millhauser, G. L., Babcock, G. F., and Abdel-Malek, Z. A. (2012) J. Invest. Dermatol., 132, 2255–2262.

    PubMed  CAS  Google Scholar 

  77. Murphy, J. R., Bishai, W., Borowski, M., Miyanohara, A., Boyd, J., and Nagle, S. (1986) Proc. Natl. Acad. Sci. USA, 83, 8258–8262.

    PubMed  CAS  Google Scholar 

  78. Wen, Z. L., Tao, X., Lakkis, F., Kiyokawa, T., and Murphy, J. R. (1991) J. Biol. Chem., 266, 12289–12293.

    PubMed  CAS  Google Scholar 

  79. Ghanem, G. E., Libert, A., Arnould, R., Vercammen, A., and Lejeune, F. (1991) Melanoma Res., 1, 105–114.

    PubMed  CAS  Google Scholar 

  80. Lejeune, F. J., and Ghanem, G. E. (1993) Ann. N. Y. Acad. Sci., 680, 391–400.

    PubMed  CAS  Google Scholar 

  81. O’Hare, K. B., Duncan, R., Strohalm, J., Ulbrich, K., and Kopeckova, P. (1993) J. Drug Target, 1, 217–229.

    PubMed  Google Scholar 

  82. Ogawa, Y., Kawahara, H., Yagi, N., Kodaka, M., Tomohiro, T., Okada, T., Konakahara, T., and Okuno, H. (1999) Lipids, 34, 387–394.

    PubMed  CAS  Google Scholar 

  83. Chan, C. K., and Jans, D. A. (2001) Gene Ther., 8, 166–171.

    PubMed  CAS  Google Scholar 

  84. Rosenkranz, A. A., Lunin, V. G., Gulak, P. V., Sergienko, O. V., Shumiantseva, M. A., Voronina, O. L., Gilyazova, D. G., John, A. P., Kofner, A. A., Mironov, A. F., Jans, D. A., and Sobolev, A. S. (2003) FASEB J., 17, 1121–1123.

    PubMed  CAS  Google Scholar 

  85. Rosenkranz, A. A., Lunin, V. G., Sergienko, O. V., Giliazova, D. G., Voronina, O. L., Ians, D. E., Kofner, A. A., Shumiantseva, M. A., Mironov, A. F., and Sobolev, A. S. (2003) Genetika, 39, 259–268.

    Google Scholar 

  86. Slastnikova, T. A., Rosenkranz, A. A., Gulak, P. V., Schiffelers, R. M., Lupanova, T. N., Khramtsov, Y. V., Zalutsky, M. R., and Sobolev, A. S. (2012) Int. J. Nanomed., 7, 467–482.

    CAS  Google Scholar 

  87. Slastnikova, T. A., Rosenkranz, A. A., Lupanova, T. N., Gulak, P. V., Gnuchev, N. V., and Sobolev, A. S. (2012) Dokl. Biochem. Biophys., 446, 235–237.

    PubMed  CAS  Google Scholar 

  88. Zhang, X., Oulad-Abdelghani, M., Zelkin, A. N., Wang, Y., Haikel, Y., Mainard, D., Voegel, J. C., Caruso, F., and Benkirane-Jessel, N. (2010) Biomaterials, 31, 1699–1706.

    PubMed  CAS  Google Scholar 

  89. Vannucci, L., Falvo, E., Fornara, M., Di Micco, P., Benada, O., Krizan, J., Svoboda, J., Hulikova-Capkova, K., Morea, V., Boffi, A., and Ceci, P. (2012) Int. J. Nanomed., 7, 1489–1509.

    CAS  Google Scholar 

  90. Kameyama, K., Montague, P. M., and Hearing, V. J. (1988) J. Cell Physiol., 137, 35–44.

    PubMed  CAS  Google Scholar 

  91. Siegrist, W., Solca, F., Stutz, S., Giuffre, L., Carrel, S., Girard, J., and Eberle, A. N. (1989) Cancer Res., 49, 6352–6358.

    PubMed  CAS  Google Scholar 

  92. Miao, Y., Whitener, D., Feng, W., Owen, N. K., Chen, J., and Quinn, T. P. (2003) Bioconj. Chem., 14, 1177–1184.

    CAS  Google Scholar 

  93. Sobolev, A. S. (2009) Biochemistry (Moscow), 74, 1567–1574.

    CAS  Google Scholar 

  94. Sobolev, A. S. (2008) Bioessays, 30, 278–287.

    PubMed  CAS  Google Scholar 

  95. Lu, W., Xiong, C., Zhang, R., Shi, L., Huang, M., Zhang, G., Song, S., Huang, Q., Liu, G. Y., and Li, C. (2012) J. Control Release, 161, 959–966.

    PubMed  CAS  Google Scholar 

  96. Abdel-Malek, Z. A. (2010) Adv. Exp. Med. Biol., 681, 126–132.

    PubMed  CAS  Google Scholar 

  97. Eberle, A. N., Bapst, J. P., Calame, M., Tanner, H., and Froidevaux, S. (2010) Adv. Exp. Med. Biol., 681, 133–142.

    PubMed  CAS  Google Scholar 

  98. Graham, M. M., and Menda, Y. (2011) J. Nucl. Med., 52, 56S–63S.

    PubMed  CAS  Google Scholar 

  99. Quinn, T., Zhang, X., and Miao, Y. (2010) G. Ital. Dermatol. Venereol., 145, 245–258.

    PubMed  CAS  Google Scholar 

  100. Haskell-Luevano, C., Nikiforovich, G., Sharma, S. D., Yang, Y. K., Dickinson, C., Hruby, V. J., and Gantz, I. (1997) J. Med. Chem., 40, 1738–1748.

    PubMed  CAS  Google Scholar 

  101. Chen, J., Cheng, Z., Miao, Y., Jurisson, S. S., and Quinn, T. P. (2002) Cancer, 94, 1196–1201.

    PubMed  CAS  Google Scholar 

  102. Chen, J., Cheng, Z., Owen, N. K., Hoffman, T. J., Miao, Y., Jurisson, S. S., and Quinn, T. P. (2001) J. Nucl. Med., 42, 1847–1855.

    PubMed  CAS  Google Scholar 

  103. Cheng, Z., Chen, J., Miao, Y., Owen, N. K., Quinn, T. P., and Jurisson, S. S. (2002) J. Med. Chem., 45, 3048–3056.

    PubMed  CAS  Google Scholar 

  104. Guo, H., Yang, J., Gallazzi, F., Prossnitz, E. R., Sklar, L. A., and Miao, Y. (2009) Bioconj. Chem., 20, 2162–2168.

    CAS  Google Scholar 

  105. Guo, H., Yang, J., Gallazzi, F., and Miao, Y. (2011) J. Nucl. Med., 52, 608–616.

    PubMed  CAS  Google Scholar 

  106. Guo, H., Shenoy, N., Gershman, B. M., Yang, J., Sklar, L. A., and Miao, Y. (2009) Nucl. Med. Biol., 36, 267–276.

    PubMed  Google Scholar 

  107. Guo, H., Yang, J., Gallazzi, F., and Miao, Y. (2010) J. Nucl. Med., 51, 418–426.

    PubMed  CAS  Google Scholar 

  108. Miao, Y., Gallazzi, F., Guo, H., and Quinn, T. P. (2008) Bioconj. Chem., 19, 539–547.

    CAS  Google Scholar 

  109. Miao, Y., Benwell, K., and Quinn, T. P. (2007) J. Nucl. Med., 48, 73–80.

    PubMed  CAS  Google Scholar 

  110. Wei, L., Zhang, X., Gallazzi, F., Miao, Y., Jin, X., Brechbiel, M. W., Xu, H., Clifford, T., Welch, M. J., Lewis, J. S., and Quinn, T. P. (2009) Nucl. Med. Biol., 36, 345–354.

    PubMed  CAS  Google Scholar 

  111. Yang, J., Guo, H., Gallazzi, F., Berwick, M., Padilla, R. S., and Miao, Y. (2009) Bioconj. Chem., 20, 1634–1642.

    CAS  Google Scholar 

  112. Yang, J., Guo, H., Padilla, R. S., Berwick, M., and Miao, Y. (2010) Bioorg. Med. Chem., 18, 6695–6700.

    PubMed  CAS  Google Scholar 

  113. Yang, J., and Miao, Y. (2012) Bioorg. Med. Chem. Lett., 22, 1541–1545.

    PubMed  CAS  Google Scholar 

  114. Raposinho, P. D., Correia, J. D., Alves, S., Botelho, M. F., Santos, A. C., and Santos, I. (2008) Nucl. Med. Biol., 35, 91–99.

    PubMed  CAS  Google Scholar 

  115. Morais, M., Oliveira, B. L., Correia, J. D., Oliveira, M. C., Jimenez, M. A., Santos, I., and Raposinho, P. D. (2013) J. Med. Chem., 56, 1961–1973.

    PubMed  CAS  Google Scholar 

  116. Guo, H., Yang, J., Shenoy, N., and Miao, Y. (2009) Bioconj. Chem., 20, 2356–2363.

    CAS  Google Scholar 

  117. Vaidyanathan, G., and Zalutsky, M. R. (1997) Nucl. Med. Biol., 24, 171–178.

    PubMed  CAS  Google Scholar 

  118. Cheng, Z., Zhang, L., Graves, E., Xiong, Z., Dandekar, M., Chen, X., and Gambhir, S. S. (2007) J. Nucl. Med., 48, 987–994.

    PubMed  CAS  Google Scholar 

  119. Ren, G., Liu, Z., Miao, Z., Liu, H., Subbarayan, M., Chin, F. T., Zhang, L., Gambhir, S. S., and Cheng, Z. (2009) J. Nucl. Med., 50, 1865–1872.

    PubMed  CAS  Google Scholar 

  120. Cantorias, M. V., Figueroa, S. D., Quinn, T. P., Lever, J. R., Hoffman, T. J., Watkinson, L. D., Carmack, T. L., and Cutler, C. S. (2009) Nucl. Med. Biol., 36, 505–513.

    PubMed  CAS  Google Scholar 

  121. Martin, M. E., Sue, O. M., Leverich, W. M., Kloepping, K. C., Walsh, S. A., and Schultz, M. K. (2013) Recent Results Cancer Res., 194, 149–175.

    PubMed  Google Scholar 

  122. McQuade, P., Miao, Y., Yoo, J., Quinn, T. P., Welch, M. J., and Lewis, J. S. (2005) J. Med. Chem., 48, 2985–2992.

    PubMed  CAS  Google Scholar 

  123. Wei, L., Butcher, C., Miao, Y., Gallazzi, F., Quinn, T. P., Welch, M. J., and Lewis, J. S. (2007) J. Nucl. Med., 48, 64–72.

    PubMed  CAS  Google Scholar 

  124. Durymanov, M. O., Slastnikova, T. A., Kuzmich, A. I., Kramtsov, Yu. V., Ulasov, A. V., Rosenkranz, A. A., Egorov, S. V., Sverdlov, E. D., and Sobolev, A. S. (2013) Biomaterials; DOI: 10.1016/j.biomaterials.2013.08.076.

    Google Scholar 

  125. Miao, Y., Owen, N. K., Fisher, D. R., Hoffman, T. J., and Quinn, T. P. (2005) J. Nucl. Med., 46, 121–129.

    PubMed  CAS  Google Scholar 

  126. Miao, Y., Hylarides, M., Fisher, D. R., Shelton, T., Moore, H., Wester, D. W., Fritzberg, A. R., Winkelmann, C. T., Hoffman, T., and Quinn, T. P. (2005) Clin. Cancer Res., 11, 5616–5621.

    PubMed  CAS  Google Scholar 

  127. Miao, Y., Shelton, T., and Quinn, T. P. (2007) Cancer Biother. Radiopharm., 22, 333–341.

    PubMed  CAS  Google Scholar 

  128. Durymanov, M. O., Beletkaia, E. A., Ulasov, A. V., Khramtsov, Y. V., Trusov, G. A., Rodichenko, N. S., Slastnikova, T. A., Vinogradova, T. V., Uspenskaya, N. Y., Kopantsev, E. P., Rosenkranz, A. A., Sverdlov, E. D., and Sobolev, A. S. (2012) J. Control Release, 163, 211–219.

    PubMed  CAS  Google Scholar 

  129. Szardenings, M., Muceniece, R., Mutule, I., Mutulis, F., and Wikberg, J. E. (2000) Peptides, 21, 239–243.

    PubMed  CAS  Google Scholar 

  130. Slastnikova, T. A., Koumarianou, E., Rosenkranz, A. A., Vaidyanathan, G., Lupanova, T. N., Sobolev, A. S., and Zalutsky, M. R. (2012) EJNMMI Res., 2, 59.

    PubMed  CAS  Google Scholar 

  131. Szardenings, M., Tornroth, S., Mutulis, F., Muceniece, R., Keinanen, K., Kuusinen, A., and Wikberg, J. E. (1997) J. Biol. Chem., 272, 27943–27948.

    PubMed  CAS  Google Scholar 

  132. Haskell-Luevano, C., Hendrata, S., North, C., Sawyer, T. K., Hadley, M. E., Hruby, V. J., Dickinson, C., and Gantz, I. (1997) J. Med. Chem., 40, 2133–2139.

    PubMed  CAS  Google Scholar 

  133. Weeden, T., Stefano, J., Duan, S., Edling, A., Hou, L., Chuang, W. L., Perricone, M. A., Pan, C., and Dzuris, J. L. (2011) J. Pept. Sci., 17, 47–55.

    PubMed  CAS  Google Scholar 

  134. Barkey, N. M., Tafreshi, N. K., Josan, J. S., De Silva, C. R., Sill, K. N., Hruby, V. J., Gillies, R. J., Morse, D. L., and Vagner, J. (2011) J. Med. Chem., 54, 8078–8084.

    PubMed  CAS  Google Scholar 

Download references

Author information

Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, 199334, Moscow, Russia

    A. A. Rosenkranz, T. A. Slastnikova, M. O. Durymanov & A. S. Sobolev

  2. Faculty of Biology, Lomonosov Moscow State University, Leninsky Gory 1-12, 119234, Moscow, Russia

    A. A. Rosenkranz, M. O. Durymanov & A. S. Sobolev

  3. Targeted Delivery of Pharmaceuticals “Translek” LLC, ul. Vavilova 34/5, 199334, Moscow, Russia

    A. A. Rosenkranz & A. S. Sobolev

Authors
  1. A. A. Rosenkranz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. A. Slastnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. O. Durymanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. S. Sobolev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. A. Rosenkranz.

Additional information

Published in Russian in Biokhimiya, 2013, Vol. 78, No. 11, pp. 1564–1575.

Electronic supplementary material

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rosenkranz, A.A., Slastnikova, T.A., Durymanov, M.O. et al. Malignant melanoma and melanocortin 1 receptor. Biochemistry Moscow 78, 1228–1237 (2013). https://doi.org/10.1134/S0006297913110035

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297913110035

Key words

  • melanoma
  • melanocortin 1 receptor
  • α-melanocyte-stimulating hormone
  • receptor
  • endocytosis
  • cancer therapy
  • diagnostics