Studies that shed new light on aging

Abstract

I will first discuss how all aging models that assume that the aged cell has irreversibly lost its youthful capabilities through such mechanisms as accumulated dysfunction, accumulated damage, and/or accumulation of toxic byproducts of metabolism have been shown to be incorrect. I will then briefly discuss models of aging and propose an experiment that would distinguish between those models and provide a basis for organismic rejuvenation.

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Correspondence to H. L. Katcher.

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Published in Russian in Biokhimiya, 2013, Vol. 78, No. 9, pp. 1354–1366.

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Katcher, H.L. Studies that shed new light on aging. Biochemistry Moscow 78, 1061–1070 (2013). https://doi.org/10.1134/S0006297913090137

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Key words

  • aging
  • aging mechanisms
  • theories of aging
  • parabiosis
  • cross-age transplantation
  • rejuvenation
  • cellular aging
  • age-dependent transcriptional patterns