Biochemistry (Moscow)

, Volume 78, Issue 8, pp 855–866 | Cite as

Protein biosynthesis in mitochondria

  • A. V. Kuzmenko
  • S. A. Levitskii
  • E. N. Vinogradova
  • G. C. Atkinson
  • V. Hauryliuk
  • N. Zenkin
  • P. A. KamenskiEmail author


Translation, that is biosynthesis of polypeptides in accordance with information encoded in the genome, is one of the most important processes in the living cell, and it has been in the spotlight of international research for many years. The mechanisms of protein biosynthesis in bacteria and in the eukaryotic cytoplasm are now understood in great detail. However, significantly less is known about translation in eukaryotic mitochondria, which is characterized by a number of unusual features. In this review, we summarize current knowledge about mitochondrial translation in different organisms while paying special attention to the aspects of this process that differ from cytoplasmic protein biosynthesis.

Key words

mitochondria translation ribosomes translation factors 



large ribosomal subunit


small ribosomal subunit


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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • A. V. Kuzmenko
    • 1
    • 2
  • S. A. Levitskii
    • 1
  • E. N. Vinogradova
    • 1
  • G. C. Atkinson
    • 2
  • V. Hauryliuk
    • 2
  • N. Zenkin
    • 3
  • P. A. Kamenski
    • 1
    Email author
  1. 1.Department of Molecular Biology, Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Institute of TechnologyUniversity of TartuTartuEstonia
  3. 3.Centre for Bacterial Cell Biology, Institute for Cell and Molecular BiosciencesNewcastle UniversityNewcastle upon TyneUK

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