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Structural organization of viral RNA-dependent RNA polymerases

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Abstract

This review describes available data on the structure of viral RNA-dependent RNA polymerases (RdRP) obtained from X-ray analysis and discusses the functional significance of the structural elements of these enzymes. Because most of the studies done to date relate to RdRP structures of picorna-, flavi-, and caliciviruses, here we consider mostly the structures of RdRP of these groups of viruses, and also include information about polymerases of other virus families.

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia

    G. S. Shatskaya & T. M. Dmitrieva

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  1. G. S. Shatskaya
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  2. T. M. Dmitrieva
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Correspondence to G. S. Shatskaya.

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Published in Russian in Biokhimiya, 2013, Vol. 78, No. 3, pp. 314–319.

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Shatskaya, G.S., Dmitrieva, T.M. Structural organization of viral RNA-dependent RNA polymerases. Biochemistry Moscow 78, 231–235 (2013). https://doi.org/10.1134/S0006297913030036

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  • DOI: https://doi.org/10.1134/S0006297913030036

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