Abstract
A protective effect of a mitochondria-targeted antioxidant, a cationic rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine-19, SkQR1) was studied in the model of open focal trauma of rat brain sensorimotor cortex. It was found that daily intraperitoneal injections of SkQR1 (100 nmol/kg) for 4 days after the trauma improved performance in a test characterizing neurological deficit and decreased the volume of the damaged cortical area. Our results suggest that SkQR1 exhibits profound neuroprotective effect, which may be explained by its antioxidative activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- MMP:
-
mitochondrial membrane permeabilization (nonspecific permeability of the inner mitochondrial membrane)
- ROS:
-
reactive oxygen species
- SkQR1:
-
10-(6′-plastoquinonyl)decylrhodamine-19
References
Liberman, E. A., Topali, V. P., Tsofina, L. M., Jasaitis, A. A., and Skulachev, V. P. (1969) Nature, 222, 1076–1078.
Grinius, L. L., Jasaitis, A. A., Kadziauskas, Yu. L., Liberman, E. A., Skulachev, V. P., Topali, V. P., Tsofina, L. M., and Vladimirova, M. A. (1970) Biochim. Biophys. Acta, 216, 1–12.
Bakeeva, L. E., Grinius, L. L., Jasaitis, A. A., Kuliene, V. V., Levitsky, D. O., Liberman, E. A., Severina, I. I., and Skulachev, V. P. (1970) Biochim. Biophys. Acta, 216, 12–21.
Liberman, E. A., and Skulachev, V. P. (1970) Biochim. Biophys. Acta, 216, 30–42.
Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., Kopnin, B. P., Korshunova, G. A., Lichinitser, M. R., Obukhova, L. A., Pasyukova, E. G., Pisarenko, O. I., Roginsky, V. A., Ruuge, E. K., Senin, I. I., Severina, I. I., Skulachev, M. V., Spivak, I. M., Tashlitsky, V. N., Tkachuk, V. A., Vyssokikh, M. Y., Yaguzhinsky, L. S., and Zorov, D. B. (2009) Biochim. Biophys. Acta, 1787, 437–461.
Skulachev, M. V., Antonenko, Y. N., Anisimov, V. N., Chernyak, B. V., Cherepanov, D. A., Chistyakov, V. A., Egorov, M. V., Kolosova, N. G., Korshunova, G. A., Lyamzaev, K. G., Plotnikov, E. Y., Roginsky, V. A., Savchenko, A. Y., Severina, I. I., Severin, F. F., Shkurat, T. P., Tashlitsky, V. N., Shidlovsky, K. M., Vyssokikh, M. Y., Zamyatnin, A. A., Jr., Zorov, D. B., and Skulachev, V. P. (2011) Curr. Drug Targets, 12, 800–826.
Bakeeva, L. E., Barskov, I. V., Egorov, M. V., Isaev, N. K., Kapelko, V. I., Kazachenko, A. V., Kirpatovsky, M. I., Kozlovsky, S. V., Lakomkin, V. L., Levina, S. V., Pisarenko, O. I., Plotnikov, E. Y., Saprunova, V. B., Serebryakova, L. I., Skulachev, M. V., Stelmashuk, E. V., Studneva, I. M., Tskitishvili, O. V., Vasil’eva, A. K., Viktorov, I. V., Zorov, D. B., and Skulachev, V. P. (2008) Biochemistry (Moscow), 73, 1288–1299.
Plotnikov, E. Y., Silachev, D. N., Chupyrkina, A. A., Danshina, M. I., Yankauskas, S. S., Morosanova, M. A., Stelmashook, E. V., Vasil’eva, A. K., Goryacheva, E. S., Pirogov, Yu. A., Isaev, N. K., and Zorov, D. B. (2010) Biochemistry (Moscow), 75, 145–150.
Kapay, N. A., Isaev, N. K., Stelmashook, E. V., Popova, O. V., Zorov, D. B., Skrebitsky, V. G., and Skulachev, V. P. (2011) Biochemistry (Moscow), 76, 1367–1370.
Andriessen, T. M., Jacobs, B., and Vos, P. E. (2010) J. Cell Mol. Med., 14, 2381–2392.
Veech, R. L., Valeri, C. R., and VanItallie, T. B. (2012) IUBMB Life, 64, 203–207.
Zorov, D. B., Filburn, C. R., Klotz, L. O., Zweier, J. L., and Sollott, S. J. (2000) J. Exp. Med., 192, 1001–1014.
Feeney, D. M., Boyeson, M. G., Linn, R. T., Murray, H. M., and Dail, W. G. (1981) Brain Res., 211, 67–77.
Hicks, S. P., and D’Amato, C. J. (1977) Exp. Neurol., 56, 410–420.
Silachev, D. N., Uchevatkin, A. A., Pirogov, Y. A., Zorov, D. B., and Isaev, N. K. (2009) Byul. Eksp. Biol. Med., 147, 232–237.
De Ryck, M., van Reempts, J., Borgers, M., Wauquier, A., and Janssen, P. A. (1989) Stroke, 20, 1383–1390.
Jolkkonen, J., Puurunen, K., Rantakomi, S., Harkonen, A., Haapalinna, A., and Sivenius, J. (2000) Eur. J. Pharmacol., 400, 211–219.
Gouriou, Y., Demaurex, N., Bijlenga, P., and De Marchi, U. (2011) Biochimie, 93, 2060–2067.
Niizuma, K., Yoshioka, H., Chen, H., Kim, G. S., Jung, J. E., Katsu, M., Okami, N., and Chan, P. H. (2010) Biochim. Biophys. Acta, 1802, 92–99.
Skulachev, V. P. (2012) J. Alzheimer’s Dis., 28, 283–289.
Plotnikov, E. Y., Chupyrkina, A. A., Jankauskas, S. S., Pevzner, I. B., Silachev, D. N., Skulachev, V. P., and Zorov, D. B. (2011) Biochim. Biophys. Acta, 1812, 77–86.
Slemmer, J. E., Shacka, J. J., Sweeney, M. I., and Weber, J. T. (2008) Curr. Med. Chem., 15, 404–414.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © N. K. Isaev, S. V. Novikova, E. V. Stelmashook, I. V. Barskov, D. N. Silachev, L. G. Khaspekov, V. P. Skulachev, D. B. Zorov, 2012, published in Biokhimiya, 2012, Vol. 77, No. 9, pp. 1201–1206.
Rights and permissions
About this article
Cite this article
Isaev, N.K., Novikova, S.V., Stelmashook, E.V. et al. Mitochondria-targeted plastoquinone antioxidant SkQR1 decreases trauma-induced neurological deficit in rat. Biochemistry Moscow 77, 996–999 (2012). https://doi.org/10.1134/S0006297912090052
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006297912090052