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Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss

Abstract

The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals’ mortality. Treatment with SkQR1 also decreases gentamycininduced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.

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Abbreviations

AKI:

acute kidney injury

ROS:

reactive oxygen species

SkQR1:

10-(6′-plastoquinonyl) decylrhodamine 19

References

  1. 1.

    Edson, R. S., and Terrell, C. L. (1999) Mayo Clin. Proc., 74, 519–528.

    PubMed  CAS  Google Scholar 

  2. 2.

    Lopez-Novoa, J. M., Quiros, Y., Vicente, L., Morales, A. I., and Lopez-Hernandez, F. J. (2011) Kidney Int., 79, 33–45.

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    Rybak, L. P., and Whitworth, C. A. (2005) Drug Discov. Today, 10, 1313–1321.

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Chen, Y., Huang, W. G., Zha, D. J., Qiu, J. H., Wang, J. L., Sha, S. H., and Schacht, J. (2007) Hear Res., 226, 178–182.

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    El Mouedden, M., Laurent, G., Mingeot-Leclercq, M. P., Taper, H. S., Cumps, J., and Tulkens, P. M. (2000) Antimicrob. Agents Chemother., 44, 665–675.

    PubMed  Article  Google Scholar 

  6. 6.

    Li, L., Nevill, G., and Forge, A. (1995) J. Comp. Neurol., 355, 405–417.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Zorov, D. B., Juhaszova, M., Yaniv, Y., Nuss, H. B., Wang, S., and Sollott, S. J. (2009) Cardiovasc. Res., 83, 213–225.

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Zorov, D. B., Isaev, N. K., Plotnikov, E. Y., Zorova, L. D., Stelmashuk, E. V., Vasil’eva, A. K., Arkhangelskaya, A. A., and Khryapenkova, T. G. (2007) Biochemistry (Moscow), 72, 1115–1126.

    Article  CAS  Google Scholar 

  9. 9.

    Morales, A. I., Detaille, D., Prieto, M., Puente, A., Briones, E., Arevalo, M., Leverve, X., Lopez-Novoa, J. M., and El-Mir, M. Y. (2010) Kidney Int., 77, 861–869.

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Dehne, N., Rauen, U., de Groot, H., and Lautermann, J. (2002) Hear Res., 169, 47–55.

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    Jung, H. H., Chang, J., Yang, J. Y., Choi, J., Im, G. J., and Chae, S. W. (2011) Hear Res., 282, 92–96.

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    Skulachev, V. P. (2007) Biochemistry (Moscow), 72, 1385–1396.

    Article  CAS  Google Scholar 

  13. 13.

    Liberman, E. A., Topaly, V. P., Tsofina, L. M., Jasaitis, A. A., and Skulachev, V. P. (1969) Nature, 222, 1076–1078.

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Plotnikov, E. Y., Chupyrkina, A. A., Jankauskas, S. S., Pevzner, I. B., Silachev, D. N., Skulachev, V. P., and Zorov, D. B. (2011) Biochim. Biophys. Acta, 1812, 77–86.

    PubMed  CAS  Google Scholar 

  15. 15.

    Plotnikov, E. Y., Vasileva, A. K., Arkhangelskaya, A. A., Pevzner, I. B., Skulachev, V. P., and Zorov, D. B. (2008) FEBS Lett., 582, 3117–3124.

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Walker, P. D., and Shah, S. V. (1987) Am. J. Physiol., 253, C495–499.

    PubMed  CAS  Google Scholar 

  17. 17.

    Keene, M., Hawke, M., Barber, H. O., and Farkashidy, J. (1982) Arch. Otolaryngol., 108, 65–70.

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Humes, H. D. (1999) Ann. N. Y. Acad. Sci., 884, 15–18.

    PubMed  CAS  Google Scholar 

  19. 19.

    Bakeeva, L. E., Barskov, I. V., Egorov, M. V., Isaev, N. K., Kapelko, V. I., Kazachenko, A. V., Kirpatovsky, V. I., Kozlovsky, S. V., Lakomkin, V. L., Levina, S. V., Pisarenko, O. I., Plotnikov, E. Y., Saprunova, V. B., Serebryakova, L. I., Skulachev, M. V., Stelmashuk, E. V., Studneva, I. M., Tskitishvili, O. V., Vasileva, A. K., Zorov, D. B., and Skulachev, V. P. (2008) Biochemistry (Moscow), 73, 1288–1299.

    Article  CAS  Google Scholar 

  20. 20.

    Zorov, D. B. (2010) Kidney Int., 77, 841–843.

    PubMed  Article  CAS  Google Scholar 

  21. 21.

    Antonenko, Y. N., Avetisyan, A. V., Bakeeva, L. E., Chernyak, B. V., Chertkov, V. A., Domnina, L. V., Ivanova, O. Y., Izyumov, D. S., Khailova, L. S., Klishin, S. S., Korshunova, G. A., Lyamzaev, K. G., Muntyan, M. S., Nepryakhina, O. K., Pashkovskaya, A. A., Pletyushkina, O. Y., Pustovidko, A. V., Roginsky, V. A., Rokitskaya, T. I., Ruuge, E. K., Saprunova, V. B., Severina, I. I., Simonyan, R. A., Skulachev, I. V., Skulachev, M. V., Sumbatyan, N. V., Sviryaeva, I. V., Tashlitsky, V. N., Vasil’ev, Y. M., Vysokikh, M. Y., Yaguzhinsky, L. S., Zamyatnin, A. A., and Skulachev, V. P. (2008) Biochemistry (Moscow), 73, 1273–1287.

    Article  CAS  Google Scholar 

  22. 22.

    Juhaszova, M., Zorov, D. B., Kim, S. H., Pepe, S., Fu, Q., Fishbein, K. W., Ziman, B. D., Wang, S., Ytrehus, K., Antos, C. L., Olson, E. N., and Sollott, S. J. (2004) J. Clin. Invest., 113, 1535–1549.

    PubMed  CAS  Google Scholar 

  23. 23.

    Sharples, E. J., and Yaquob, M. M. (2006) Semin. Nephrol., 26, 325–331.

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Monge, A., Nagy, I., Bonabi, S., Schmid, S., Gassmann, M., and Bodmer, D. (2006) Laryngoscope, 116, 312–316.

    PubMed  Article  CAS  Google Scholar 

  25. 25.

    Mathews, A., and Bailie, G. R. (1987) J. Clin. Pharm. Ther., 12, 273–291.

    PubMed  Article  CAS  Google Scholar 

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Correspondence to E. Y. Plotnikov or D. B. Zorov.

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Original Russian Text © S. S. Jankauskas, E. Y. Plotnikov, M. A. Morosanova, I. B. Pevzner, L. D. Zorova, V. P. Skulachev, D. B. Zorov, 2012, published in Biokhimiya, 2012, Vol. 77, No. 6, pp. 818–823.

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Jankauskas, S.S., Plotnikov, E.Y., Morosanova, M.A. et al. Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss. Biochemistry Moscow 77, 666–670 (2012). https://doi.org/10.1134/S0006297912060144

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Key words

  • kidney
  • organ of Corti
  • mitochondria
  • antioxidant
  • nephrotoxicity
  • ototoxicity
  • antibiotics