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Interaction of the nitric oxide signaling system with the Sphingomyelin cycle and Peroxidation on transmission of toxic signal of tumor necrosis factor-α in ischemia-reperfusion

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Abstract

This review discusses the functional role of nitric oxide in ischemia-reperfusion injury and mechanisms of signal transduction of apoptosis, which accompanies ischemic damage to organs and tissues. On induction of apoptosis an interaction is observed of the nitric oxide signaling system with the sphingomyelin cycle, which is a source of a proapoptotic agent ceramide. Evidence is presented of an interaction of the sphingomyelin cycle enzymes and ceramide with nitric oxide and enzymes synthesizing nitric oxide. The role of a proinflammatory cytokine TNF-α in apoptosis and ischemia-reperfusion and mechanisms of its cytotoxic action, which involve nitric oxide, the sphingomyelin cycle, and lipid peroxidation are discussed. A comprehensive study of these signaling systems provides insight into the molecular mechanism of apoptosis during ischemia and allows us to consider new approaches for treatment of diseases associated with the activation of apoptosis.

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Abbreviations

BHA:

butylhydroxyanisole

CAPK:

ceramide-activated protein kinase

CAPP:

ceramide-activated protein phosphatase

cGMP:

cyclic guanidine monophosphate

DNIC:

dinitrosyl iron complexes

DPI:

diphenyl iodonium

eNOS:

endothelial NO synthase

GSH:

glutathione

GSNO:

nitrosoglutathione

HNE:

4-hydroxy-2-nonenal

iNOS:

inducible NO synthase

L-NAME-NG :

nitro-L-arginine methyl ester

LPO:

lipid peroxidation

nNOS:

neuronal NO synthase

NO:

nitric oxide

3-NP:

3-nitropropionic acid

PK:

protein kinase

ROS:

reactive oxygen species

sGC:

soluble guanylate cyclase

SPM:

sphingomyelin

SPMase:

sphingomyelinase

SPM cycle:

sphingomyelin cycle

TNF-α:

tumor necrosis factor α

TNF-R1, TNF-R2:

TNF-α-binding receptors

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  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119334, Moscow, Russia

    M. A. Shupik & A. V. Alessenko

  2. Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119334, Moscow, Russia

    A. F. Vanin

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Original Russian Text © M. A. Shupik, A. F. Vanin, A. V. Alessenko, 2011, published in Biokhimiya, 2011, Vol. 76, No. 11, pp. 1489–1504.

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Shupik, M.A., Vanin, A.F. & Alessenko, A.V. Interaction of the nitric oxide signaling system with the Sphingomyelin cycle and Peroxidation on transmission of toxic signal of tumor necrosis factor-α in ischemia-reperfusion. Biochemistry Moscow 76, 1197–1209 (2011). https://doi.org/10.1134/S0006297911110010

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