Skip to main content
SpringerLink
Log in

Effect of Plastoquinone Derivative 10-(6′-Plastoquinonyl)decyltriphenylphosphonium (SkQ1) on Contents of Steroid Hormones and NO Level in Rats

  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

An Erratum to this article was published on 17 June 2011

Abstract

Introduction of the plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17ß-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%, respectively. ESR spectroscopy with diethyldithiocarbamate-iron complex as a spin trap showed more than twofold increase in NO production in lungs, but not in blood, liver, and intestines, following the SkQ1 daily introduction at a dose of 25 nmol/kg.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Filenko, O. F., Isakova, E. F., Manskikh, V, N., Michelson, V. M., Panteleeva, A. A., Pasyukova, E. G., Pilipenko, D. I., Piskunova, T. S., Popovich, I. G., Roshchina, N. V., Rybina, O. Yu., Saprunova, V. B., Samoylova, T. A., Semenchenko, A. V., Skulachev, M. V., Spivak, I. M., Tsybul’ko, E. A., Tyndyk, M. L., Vyssokikh, M. Yu., Yurova, M. N., Zabezhinsky, M. A., and Skulachev, V. P. (2008) Biochemistry (Moscow), 73, 1329–1342.

    Article  CAS  Google Scholar 

  2. Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., Kopnin, B. P., Korshunova, G. A., Lichinitser, M. R., Obukhova, L. A., Pasyukova, E. G., Pisarenko, O. I., Roginsky, V. A., Ruuge, E. K., Senin, I. I., Severina, I. I., Skulachev, M. V., Spivak, I. M., Tashlitsky, V. N., Tkachuk, V. A., Vyssokikh, M. Y., Yaguzhinsky, L. S., and Zorov, D. B. (2009) Biochim. Biophys. Acta, 1787, 437–461.

    Article  PubMed  CAS  Google Scholar 

  3. Vina, J., Sastre, J., Pallardo, V. F., Gambini, J., and Borras, C. (2008) Biol. Chem., 389, 273–277.

    Article  PubMed  CAS  Google Scholar 

  4. Hamden, K., Carreau, S., Ellouz, F., Masmoudi, H., and Elfeki, A. (2007) J. Physiol. Biochem., 63, 195–201.

    Article  PubMed  CAS  Google Scholar 

  5. Hamden, K., Carreau, S., Boujbiha, M. A., Lajmi, S., Aloulou, D., Kchaou, D., and Elfeki, A. (2008) Steroids, 73, 495–501.

    Article  PubMed  CAS  Google Scholar 

  6. Pedram, A., Razandi, M., Wallace, D. C., and Levin, E. R. (2006) Mol. Biol. Cell, 17, 2125–2137.

    Article  PubMed  CAS  Google Scholar 

  7. Weiner, C. P., Lizasoain, I., Baylis, S. A., Knowles, G., Charles, I. C., and Moncada, S. (1994) Proc. Natl. Acad. Sci. USA, 91, 5212–5216.

    Article  PubMed  CAS  Google Scholar 

  8. Simoncini, T., and Genazzani, A. R. (2003) Eur. J. Endocrinol., 148, 281–292.

    Article  PubMed  CAS  Google Scholar 

  9. Cicinelli, E., Ignarro, L. J., Lograno, M., Galantino, P., Balzano, G., and Schonauer, L. M. (1996) Fertil. Steril., 66, 1036–1038.

    PubMed  CAS  Google Scholar 

  10. Stefano, G. B., Prevot, V., Beauvillain, J.-C., Cadet, P., Fimiani, C., Welters, I., Fricchione, G. L., Breton, C., Lassalle, P., Salzet, M., and Bilfinger, T. V. (2000) Circulation, 101, 1594–1597.

    PubMed  CAS  Google Scholar 

  11. Murphy, E., and Steenbergen, C. (2007) Cardiovasc. Res., 75, 478–486.

    Article  PubMed  CAS  Google Scholar 

  12. Tarpey, M. M., and Fridovich, I. (2001) Circ. Res., 89, 224–236.

    Article  PubMed  CAS  Google Scholar 

  13. Golikov, P. P. (2004) Nitric Oxide in Pattern of Emergency Diseases [in Russian], Medpraktika, Moscow.

  14. Mikoyan, V. D., Serezhenkov, V. A., Brazhnikova, N. V., Kubrina, L. N., Khachatryan, G. N., and Vanin, A. F. (2004) Biophysics (Moscow), 49, 110–116.

    Google Scholar 

  15. Glantz, S. A. (2005) Primer of Biostatistics, 6th Edn., McGraw-Hill Co., N.-Y.

  16. Hu, J., Zhang, Z., Shen, W. J., and Azhar, S. (2010) Nutr. Metab. (Lond.), 7, 47–73.

    Article  Google Scholar 

  17. Severin, F. F., Severina, I. I., Antonenko, Y. N., Rokitskaya, T. I., Cherepanov, D. A., Mokhova, E. N., Vyssokikh, M. Y., Pustovidko, A. V., Markova, O. V., Yaguzhinsky, L. S., Korshunova, G. A., Sumbatyan, N. V., Skulachev, M. V., and Skulachev, V. P. (2010) Proc. Natl. Acad. Sci. USA, 107, 663–668.

    Article  PubMed  CAS  Google Scholar 

  18. Strauss, J. F., 3rd, Kishida, T., Christenson, L. K., Fujimoto, T., and Hiroi, H. (2003) Mol. Cell. Endocrinol., 202, 59–65.

    PubMed  CAS  Google Scholar 

  19. Nilsen, J. (2008) Front. Neuroendocrinol., 29, 463–475.

    Article  PubMed  CAS  Google Scholar 

  20. Bakeeva, L. E., Barskov, I. V., Egorov, M. V., Isaev, N. K., Kapel’ko, V. I., Kazachenko, A. V., Kirpatovsky, V. I., Kozlovsky, S. V., Lakomkin, V. L., Levina, S. V., Pisarenko, O. I., Plotnikov, E. Yu., Saprunova, V. B., Serebryakova, L. I., Skulachev, M. V., Stelmashook, E. V., Studneva, I. M., Tskitishvili, O. V., Vasilyeva, A. K., Viktorov, I. V., Zorov, D. B., and Skulachev, V. P. (2008) Biochemistry (Moscow), 73, 1288–1299.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Biology, Southern Federal University, pr. Stachky 194/1 o344090, Rostov-na-Donu, Russia

    V. A. Chistyakov, A. A. Alexandrova, N. P. Milyutina, V. N. Prokof’ev, E. V. Mashkina, L. V. Gutnikova & S. V. Dem’yanenko

  2. Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119991, Moscow, Russia

    V. A. Serezhenkov

Authors
  1. V. A. Chistyakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Serezhenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Alexandrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. P. Milyutina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. N. Prokof’ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. V. Mashkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. V. Gutnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. V. Dem’yanenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Original Russian Text © V. A. Chistyakov, V. A. Serezhenkov, A. A. Alexandrova, N. P. Milyutina, V. N. Prokof’ev, E. V. Mashkina, L. V. Gutnikova, S. V. Dem’yanenko, 2010, published in Biokhimiya, 2010, Vol. 75, No. 11, pp. 1571–1576.

An erratum to this article can be found at http://dx.doi.org/10.1134/S0006297911060150

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chistyakov, V.A., Serezhenkov, V.A., Alexandrova, A.A. et al. Effect of Plastoquinone Derivative 10-(6′-Plastoquinonyl)decyltriphenylphosphonium (SkQ1) on Contents of Steroid Hormones and NO Level in Rats. Biochemistry Moscow 75, 1383–1387 (2010). https://doi.org/10.1134/S0006297910110106

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297910110106

Key words

Search

Navigation