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Oxidative stress in yeast

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Abstract

The mechanisms of production and elimination of reactive oxygen species in the cells of the budding yeast Saccharomyces cerevisiae are analyzed. Coordinative role of special regulatory proteins including Yap1p, Msn2/4p, and Skn7p (Pos9p) in regulation of defense mechanisms in S. cerevisiae is described. A special section is devoted to two other well-studied species from the point of view of oxidative stress — Schizosaccharomyces pombe and Candida albicans. Some examples demonstrating the use of yeast for investigation of apoptosis, aging, and some human diseases are given in the conclusion part.

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Abbreviations

AMT:

aminotriazole

cAMP-PKA:

cAMP-dependent protein kinase A

DDC:

diethyldithiocarbamate

G6PDH:

glucose-6-phosphate dehydrogenase

ROS:

reactive oxygen species

SOD:

superoxide dismutase

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  1. Department of Biochemistry, Vassyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76025, Ukraine

    V. I. Lushchak

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Published in Russian in Biokhimiya, 2010, Vol. 75, No. 3, pp. 346–364.

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Lushchak, V.I. Oxidative stress in yeast. Biochemistry Moscow 75, 281–296 (2010). https://doi.org/10.1134/S0006297910030041

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