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Dynamics of nonmembranous cell components: Role of active transport along microtubules

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Abstract

Here we discuss some common mechanisms of microtubule-dependent active transport of nonmembranous components in animal cells. We summarize data about mRNA, cytoskeletal elements, structural proteins, and signaling complexes transport. We also characterize the series of molecular interactions that connect nonmembranous cargoes and microtubules and describe the regulatory pathways for these interactions.

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Abbreviations

APC:

adenoma polyposis coli protein

CPE:

cytoplasmic polyadenylation element

MSD:

mean squared displacement

NLS:

nuclear localization signal

RNP:

ribonucleoprotein

UTR:

untranslated region

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Authors and Affiliations

  1. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991, Moscow, Russia

    A. Yu. Lomakin

  2. Institute of Protein Research, Russian Academy of Sciences, ul. Institutskaya 4, 142290, Pushchino, Russia

    E. S. Nadezhdina

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  1. A. Yu. Lomakin
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  2. E. S. Nadezhdina
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Correspondence to E. S. Nadezhdina.

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Original Russian Text © A. Yu. Lomakin, E. S. Nadezhdina, 2010, published in Biokhimiya, 2010, Vol. 75, No. 1, pp. 12–26.

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Lomakin, A.Y., Nadezhdina, E.S. Dynamics of nonmembranous cell components: Role of active transport along microtubules. Biochemistry Moscow 75, 7–18 (2010). https://doi.org/10.1134/S0006297910010025

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  • DOI: https://doi.org/10.1134/S0006297910010025

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