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Biochemistry (Moscow)

, Volume 75, Issue 1, pp 1–6 | Cite as

An overview on nucleases (DNase, RNase, and phosphodiesterase) in snake venoms

  • B. L. Dhananjaya
  • C. J. M. D’souzaEmail author
Review

Abstract

In this review, we have compiled the data on pharmacological activities associated with endogenous purine release related enzymes—nucleases (DNases, RNases, and phosphodiesterases). The results of studies on toxic effects of these enzymes, emphasizing the future directions in this field, are summarized. One of the major problems facing toxicologists is the identification and characterization of specific venom nucleases since they share similar substrate specificities and biochemical properties. In this review, we have attempted to clarify some of the discrepancies about these enzymes. Further, we have tried to correlate the existence of nuclease enzymes in relation to endogenous release of purines, a multitoxin, during snake envenomation, and we also discuss the possible actions of purines. We hope that this review will stimulate renewed interest among toxicologists to biologically characterize these enzymes and elucidate their role in envenomation.

Key words

purines DNase RNase phosphodiesterase snake envenomation adenosine 

Abbreviations

EST

expressed sequence tag

PDE

phosphodiesterase

PLA2

phospholipase A2

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Department of Studies in BiochemistryUniversity of MysoreManasagangothri, MysoreIndia

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