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Free radicals and cell chemiluminescence

Biochemistry (Moscow) volume 74, pages 1545–1566 (2009)Cite this article

Abstract

Application of chemiluminescence (CL) for study of free-radical reactions in human and animal cells and tissues is considered in this review. Historically, the study of intrinsic (ultraweak) luminescence gave place to the measurement of CL in the presence of chemical activators (CL probes) and physical activators (sensitizers) of luminescence, which made the method much more sensitive and specific. The methods of CL and EPR are direct methods of radical investigation, though the advantage of the CL method consists in the fact that CL intensity is directly proportional to a steady-state concentration of the radicals responsible for luminescence (first of all, lipid and oxygen radicals) irrespective the activity of these radicals. The mechanisms of CL reactions in the absence of activators and in the presence of luminol and lucigenin are considered. Examples of various applications of the CL method in medical, biological, and clinical investigations are given including those for estimation of the phagocytic activity of cells, antioxidant activity, determination of toxicity, and other purposes.

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Abbreviations

CL:

chemiluminescence

CL probe:

chemiluminescent probe (a chemical compound that enters into a CL reaction with active molecules: free radicals, peroxides, hypochlorite, etc.)

CL reaction:

chemiluminescence reaction (a chemical reaction accompanied by light radiation — in visible, UV, or near IR spectral region)

Coum-CL:

isoquinolizine coumarin C-525-enhanced chemiluminescence

EPR:

electron paramagnetic resonance spectroscopy

ICL:

intrinsic chemiluminescence (ultraweak luminescence)

LCL:

chemiluminescence in the presence of luminol

LPO:

free-radical chain (peroxide) lipid oxidation

Luc-CL:

chemiluminescence in the presence of lucigenin

ROS:

reactive oxygen species

SAR:

superoxide anion-radical (·OO−)

TAR:

total antioxidant reactivity

TRAP:

total reactive antioxidant potentials

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  1. Faculty of Basic Medicine, Lomonosov Moscow State University, Lomonosovsky pr. 31/5, 117192, Moscow, Russia

    Yu. A. Vladimirov & E. V. Proskurnina

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Original Russian Text © Yu. A. Vladimirov, E. V. Proskurnina, 2009, published in Uspekhi Biologicheskoi Khimii, 2009, Vol. 49, pp. 341–388.

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Vladimirov, Y.A., Proskurnina, E.V. Free radicals and cell chemiluminescence. Biochemistry Moscow 74, 1545–1566 (2009). https://doi.org/10.1134/S0006297909130082

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Key words

  • chemiluminescence
  • reactive oxygen species
  • luminol
  • lucigenin
  • cell luminescence
  • lipid peroxidation