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Biochemistry (Moscow)

, Volume 73, Issue 12, pp 1329–1342 | Cite as

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

  • V. N. Anisimov
  • L. E. Bakeeva
  • P. A. Egormin
  • O. F. Filenko
  • E. F. Isakova
  • V. N. Manskikh
  • V. M. Mikhelson
  • A. A. Panteleeva
  • E. G. Pasyukova
  • D. I. Pilipenko
  • T. S. Piskunova
  • I. G. Popovich
  • N. V. Roshchina
  • O. Yu. Rybina
  • V. B. Saprunova
  • T. A. Samoylova
  • A. V. Semenchenko
  • M. V. Skulachev
  • I. M. Spivak
  • E. A. Tsybul’ko
  • M. L. Tyndyk
  • M. Yu. Vyssokikh
  • M. N. Yurova
  • M. A. Zabezhinsky
  • V. P. SkulachevEmail author
Article

Abstract

Very low (nano- and subnanomolar) concentrations of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.

Key words

SkQ1 antioxidants mitochondria aging senescence therapy 

Abbreviations

C12TPP

dodecyltriphenylphosphonium

MitoQ

10-(6′-ubiquinonyl) decyltriphenylphosphonium

PQ

decyl plastoquinone

ROS

reactive oxygen species

SkQs

cationic derivatives of plastoquinone or methyl plastoquinone

SkQ1

10-(6′-plastoquinonyl) decyltriphenylphosphonium

SkQR1

10-(6′-plastoquinonyl) decylrhodamine 19

TPP

tetraphenylphosphonium

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • V. N. Anisimov
    • 1
  • L. E. Bakeeva
    • 2
  • P. A. Egormin
    • 1
  • O. F. Filenko
    • 3
  • E. F. Isakova
    • 3
  • V. N. Manskikh
    • 4
  • V. M. Mikhelson
    • 5
  • A. A. Panteleeva
    • 2
  • E. G. Pasyukova
    • 6
  • D. I. Pilipenko
    • 2
  • T. S. Piskunova
    • 1
  • I. G. Popovich
    • 1
  • N. V. Roshchina
    • 6
  • O. Yu. Rybina
    • 6
  • V. B. Saprunova
    • 2
  • T. A. Samoylova
    • 3
  • A. V. Semenchenko
    • 1
  • M. V. Skulachev
    • 4
  • I. M. Spivak
    • 5
  • E. A. Tsybul’ko
    • 6
  • M. L. Tyndyk
    • 1
  • M. Yu. Vyssokikh
    • 2
  • M. N. Yurova
    • 1
  • M. A. Zabezhinsky
    • 1
  • V. P. Skulachev
    • 2
    • 4
    • 7
    Email author
  1. 1.Petrov Institute of OncologySt. PetersburgRussia
  2. 2.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  3. 3.Biological FacultyLomonosov Moscow State UniversityMoscowRussia
  4. 4.Mitoengineering CenterLomonosov Moscow State UniversityMoscowRussia
  5. 5.Institute of CytologyRussian Academy of SciencesSt. PetersburgRussia
  6. 6.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia
  7. 7.Faculty of Bioengineering and BioinformaticsLomonosov Moscow State UniversityMoscowRussia

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