Abstract
In the absence of exogenous polyamines, the polyamine-deficient Escherichia coli mutant shows not only a characteristic dual-phase growth with abnormal growth, growth arrest, and normal growth after mutation, but also a higher expression of the SOS genes than the polyamine-proficient wild type. The interval of the growth arrest is inversely regulated in a polyamine concentration-dependent manner. These results indicate that the polyamines can act as a signal not only for provoking an adaptive mutation, but also for hastening generation of an adaptive mutation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- LB:
-
Luria-Bertani medium
- PBS:
-
phosphate-buffered saline
References
Bjed, I., Tenaillon, O., Gerard, B., Souza, V., Denamur, E., Radman, M., Taddei, F., and Matic, I. (2003) Science, 300, 1404–1409.
Shankel, D. M., Hartman, P. E., Kada, T., and Hollaender, A. (1987) Environ. Mutagen., 9, 87–103.
Strauss, B. S. (1998) Genetics, 148, 1619–1626.
Drake, J. W. (1991) Annu. Rev. Genet., 25, 125–146.
Foster, P. L. (1993) Annu. Rev. Microbiol., 47, 457–504.
Hall, B. G. (1992) Curr. Opin. Genet. Dev., 2, 943–946.
Harris, R. S., Longerich, S., and Rosenberg, S. M. (1994) Science, 264, 258–260.
Rosenberg, S. M., and Hastings, P. J. (2003) Science, 300, 1382–1383.
Finch, C. E., and Goodman, M. F. (1997) Trends Neurosci., 20, 501–507.
Foster, P. L. (1999) Annu. Rev. Genet., 33, 57–88.
Rosenberg, S. M. (2001) Nat. Rev. Genet., 504–515.
Echols, H. (1981) Cell, 25, 1–2.
Radman, M. (1975) Basic Life Sci., 5A, 355–367.
Geiger, L. E., and Morris, D. R. (1980) J. Bacteriol., 141, 1192–1198.
Jung, I. L., and Kim, I. G. (2003) J. Biol. Chem., 278, 22846–22852.
Jung, I. L., and Kim, I. G. (2003) Cell. Biol. Toxicol., 19, 29–41.
Jung, I. L., and Kim, I. G. (2003) Environ. Toxicol. Pharmacol., 15, 19–26.
Jung, I. L., and Kim, I. G. (2003) Biochem. Biophys. Res. Commun., 301, 915–922.
Jung, I. L., Oh, T. J., and Kim, I. G. (2003) Arch. Biochem. Biophys., 418, 125–132.
Tkachenko, A. G., Nesterova, L., and Pshenichnov, M. (2001) Arch. Microbiol., 176, 155–157.
Tkachenko, A. G., and Fedotova, M. V. (2007) Biochemistry (Moscow), 72, 109–116.
Miller, J. H. (1972) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
Friedberg, E. C., Walker, G. C., and Siede, W. (1995) American Society for Microbiology, Washington, DC.
Taddei, F., Halliday, J. A., Matic, I., and Radman, M. (1997) Mol. Gen. Genet., 256, 277–281.
Fijalkowska, I. J., Dunn, R. L., and Schaaper, R. M. (1997) J. Bacteriol., 179, 7435–7445.
McMurry, L. M., and Algranati, I. D. (1986) Eur. J. Biochem., 155, 383–390.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Russian in Biokhimiya, 2008, Vol. 73, No. 11, pp. 1529–1537.
Originally published in Biochemistry (Moscow) On-Line Papers in Press, as Manuscript BM08-015, September 21, 2008.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Jung, I.L., Kim, I.G. Polyamine as a signaling molecule for controlling an adaptive mutation. Biochemistry Moscow 73, 1228–1234 (2008). https://doi.org/10.1134/S0006297908110096
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006297908110096