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Tissue-specific transcription factors in progression of epithelial tumors

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Abstract

Dedifferentiation and epithelial-mesenchymal transition are important steps in epithelial tumor progression. A central role in the control of functional and morphological properties of different cell types is attributed to tissue-specific transcription factors which form regulatory cascades that define specification and differentiation of epithelial cells during embryonic development. The main principles of the action of such regulatory systems are reviewed on an example of a network of hepatocyte nuclear factors (HNFs) which play a key role in establishment and maintenance of hepatocytes—the major functional type of liver cells. HNFs, described as proteins binding to promoters of most hepatospecific genes, not only control expression of functional liver genes, but are also involved in regulation of proliferation, morphogenesis, and detoxification processes. One of the central components of the hepatospecific regulatory network is nuclear receptor HNF4α. Derangement of the expression of this gene is associated with progression of rodent and human hepatocellular carcinomas (HCCs) and contributes to increase of proliferation, loss of epithelial morphology, and dedifferentiation. Dysfunction of HNF4α during HCC progression can be either caused by structural changes of this gene or occurs due to modification of up-stream regulatory signaling pathways. Investigations preformed on a model system of the mouse one-step HCC progression have shown that the restoration of HNF4α function in dedifferentiated cells causes partial reversion of malignant phenotype both in vitro and in vivo. Derangement of HNFs function was also described in other tumors of epithelial origin. We suppose that tissue-specific factors that underlie the key steps in differentiation programs of certain tissues and are able to receive or modulate signals from the cell environment might be considered as promising candidates for the role of tumor suppressors in the tissue types where they normally play the most significant role.

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Abbreviations

AFP:

α-fetoprotein

CDK:

cyclin-dependent kinase

ECM:

extracellular matrix

EGF:

epidermal growth factor

EHS-matrix:

three-dimensional matrix produced by cells of the Engelbreth-Holm-Swarm mouse sarcoma

EMT:

epithelial-mesenchymal transition

FGF:

fibroblast growth factor

HCC:

hepatocellular carcinoma

HGF/SF:

hepatocyte growth factor

HNF:

hepatocyte nuclear factor

IGF:

insulin-like growth factor

PI[4,5]P2 :

phosphatidylinositol 4,5-diphosphate

TGFβ:

transforming growth factor β

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  1. Institute of Carcinogenesis, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, 115478, Moscow, Russia

    N. L. Lazarevich & D. I. Fleishman

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Original Russian Text © N. L. Lazarevich, D. I. Fleishman, 2008, published in Biokhimiya, 2008, Vol. 73, No. 5, pp. 713–734.

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Lazarevich, N.L., Fleishman, D.I. Tissue-specific transcription factors in progression of epithelial tumors. Biochemistry Moscow 73, 573–591 (2008). https://doi.org/10.1134/S0006297908050106

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