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Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors

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Abstract

The appearance of antibodies to cancer-associated antigens in biological fluids (particularly, in blood sera) of cancer patients is now a well-established fact, and their detection by immunochemical methods is a promising approach to diagnostics of malignant neoplasms. In this review, we consider some immunobiological aspects of the most extensively studied cancer-associated B-cell antigens, various applications of autoantibodies as cancer biomarkers, and prospects for the use of antigen arrays for improving diagnostic sensitivity.

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Abbreviations

DTC:

differentiated thyroid cancer

NUC:

non-specific ulcerative colitis

PNS:

paraneoplastic neurological syndrome

PSA:

prostate-specific antigen

Tg-Ab:

anti-thyroglobulin antibodies

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, 119991, Moscow, Russia

    P. V. Belousov, D. V. Kuprash, D. N. Penkov & S. A. Nedospasov

  2. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    A. Yu. Sazykin, S. V. Khlgatian, Yu. V. Shebzukhov & S. A. Nedospasov

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  1. P. V. Belousov
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  4. S. V. Khlgatian
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  5. D. N. Penkov
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  6. Yu. V. Shebzukhov
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  7. S. A. Nedospasov
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Correspondence to P. V. Belousov.

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Original Russian Text © P. V. Belousov, D. V. Kuprash, A. Yu. Sazykin, S. V. Khlgatian, D. N. Penkov, Yu. V. Shebzukhov, S. A. Nedospasov, 2008, published in Biokhimiya, 2008, Vol. 73, No. 5, pp. 699–712.

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Belousov, P.V., Kuprash, D.V., Sazykin, A.Y. et al. Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors. Biochemistry Moscow 73, 562–572 (2008). https://doi.org/10.1134/S000629790805009X

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  • DOI: https://doi.org/10.1134/S000629790805009X

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