Abstract
In this review the role of molecular markers for the assessment of individual exposure to carcinogenic agents was analyzed. Examples of the studies describing mutation patterns related to specific carcinogenic exposures are presented. The results of epidemiological studies of gene polymorphism and its role in the interaction between inheritance, environmental factors, and lifestyles are analyzed in detail. Adequate planning and performance of the epidemiological component of a study is a requirement for obtaining reproducible results reflecting molecular mechanisms of interest. Individual information on lifestyle factors (smoking, alcohol consumption, nutrition, physical activity, reproductive anamnesis) and environmental factors (occupational activity and carcinogen load at workplace), which influence not only the risk of developing cancer, but also the molecular features of a tumor, is crucial for adequate analysis and proper assessment of the results.
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Abbreviations
- CI:
-
confidence interval
- GST:
-
glutathione S-transferase
- NAT:
-
N-acetyl transferase
- PAH:
-
polycyclic aromatic hydrocarbons
- RR:
-
relative risk
- TSN:
-
tobacco specific nitrosamines
- UADO:
-
upper aerodigestive organs
References
Zaridze, D. G. (1996) Arkh. Patol., 58, 45–49.
Perera, F. P. (2000) J. Natl. Cancer Inst., 92, 602–612.
Rothmans, N., Wacholder, S., Caporaso, N. E., Garcia-Closas, M., Buetoco, K., and Fraumeni, J. F. (2001) Biophys. Acta, 1471, C1–10.
Garcia-Closas, M., Vermenlen, R., Sherman, M. E., Meore, L. E., Smith, M. T., and Roman, N. (2006) in Cancer Epidemiology (Schottenfeld, D., and Fraumeni, J. F., eds.) 3rd Edn., Oxford University Press, Oxford, pp. 70–88.
Barr, D. B., and Needham, L. L. (2002) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 778, 5–29.
Atawodi, S. E., Lea, S., Nyberg, F., Mukeria, A., Constantinescu, V., Ahrens, W., Brueske-Hohlfeld, I., Fortes, C., Boffetta, P., and Friesen, M. D. (1998) Cancer Epidemiol. Biomarkers Prev., 7, 817–821.
Godschalk, R. W. L., Feldker, D. E. M., Borm, P. J. A., Wouters, E. F. M., and van Schooten, F. J. (2003) Cancer Epidemiol. Biomarkers Prev., 11, 790–793.
Zaridze, D. G. (2004) in Carcinogenesis (Zaridze, D. G., ed.) [in Russian], Meditsina, Moscow, pp. 29–85.
Pfeifer, D. H., and Hainaut, P. (2003) Mutat. Res., 526, 39–43.
Le Calvez, F., Mukeria, A., Hunt, J., Kelm, O., Hung, R., Taniere, P., Brennan, P., Boffetta, P., Zaridze, D., and Hainaut, P. (2005) Cancer Res., 65, 5076–5083.
Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., Fujisawa, T., Feng, Z., Roth, J. A., Herz, J., Minna, J. D., and Gazdar, A. (2005) J. Natl. Cancer Inst., 97, 339–346.
Shigematsu, H., Takahashi, T., Nomura, M., Majmudar, K., Suzuki, M., Lee, H., Wistuba, I. I., Fong, K. M., Toyooka, S., Shimizu, N., Fujisawa, T., Minna, J. D., and Gazdar, A. F. (2005) Cancer Res., 65, 1642–1646.
Mounawar, M., Mukeria, A., le Calvez, F., Hung, R. J., Renard, H., Cortot, A., Bollart, C., Zaridze, D., Brennan, P., Boffetta, P., Brambilla, E., and Hainaut, P. (2007) Cancer Res., 67, 5667–5672.
Kopnin, B. P. (2004) in Carcinogenesis (Zaridze, D. G., ed.) [in Russian], Meditsina, Moscow, pp. 125–156.
Wacholder, S., Chanock, S., Garcia-Closas, M., El Ghormli, L., and Rottiman, N. (2004) J. Natl. Cancer Inst., 96, 434–442.
Marchini, J., Cardon, L. R., Phillips, M. S., and Donnelly, P. (2004) Nat. Genet., 36, 512–517.
Garcia-Crosas, M., Malats, N., Silverman, D., Dosemeci, M., Kogevinas, M., Hein, D. W., Turdon, A., Serra, C., Carrato, A., Wacholder, S., and Rothman, N. (2005) Lancet, 366, 649–659.
Belitskii, G. A., and Turusov, V. S. (2004) in Carcinogenesis (Zaridze, D. G., ed.) [in Russian], Meditsina, Moscow, pp. 225–250.
Caporaso, N. E. (2006) in Cancer Epidemiology (Schottenfeld, D., and Fraumeni, J. F., eds.) 3rd Edn., Oxford University Press, Oxford, pp. 577–602.
Vineis, P., Veglia, F., Benhamou, S., Butkiewicz, D., Cascorbi, I., Clapper, M. L., Dolzan, V., Haugen, A., Hirvonen, A., Ingelman-Sundberg, M., Kihara, M., Kiyohara, C., Kremers, P., le Marchand, L., Ohshima, S., Pastorelli, R., Rannug, A., Romkes, M., Schoket, B., Shields, P., Strange, R. C., Stacker, I., Sugimura, H., Garte, S., Gaspari, L., and Taioli, E. (2003) Int. J. Cancer, 104, 650–657.
Hung, R. J., Boffetta, P., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M. L., Garte, S., Haugen, A., Hirvonen, A., Anttila, S., Kalina, I., le Marchand, L., London, S. J., Rannug, A., Romkes, M., Salagovic, J., Schoket, B., Gaspari, L., and Taioli, E. (2003) Carcinogenesis, 24, 875–882.
Gemignani, F., Landi, S., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Foretova, L., Janout, V., Bencko, V., Gaborieau, V., Gioia-Patricola, L., Bellini, I., Barale, R., Canzian, F., Hall, J., Boffetta, P., Hung, R. J., and Brennan, P. (2007) Carcinogenesis, 28, 1287–1293.
Hein, D. W. (2006) Oncogene, 25, 1649–1658.
Wikman, H., Thiel, S., Jager, B., Schmerer, P., Spiegelhalder, B., Edler, L., Dienemann, H., Kayser, K., Schulz, V., Drings, P., Bartsch, H., and Risch, A. (2001) Pharmacogenetics, 11, 157–168.
McKay, J. D., Hashibe, M., Hung, R. J., Wakefield, J., Gaborieau, V., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Chabrier, A., Hall, J., Boffetta, P., Canzian, F., and Brennan, P. (2008) Cancer Epidemiol. Biomarkers Prev., 17, 141–147.
Malats, N., Camus-Radon, A.-M., Nyberg, F., Ahrens, W., Constantinescu, V., Mukeria, A., Benhamou, S., Batura-Gabryel, H., Bruske-Hohlfeld, I., Simonato, L., Menezes, A., Lea, S., Lang, M., and Boffetta, P. (2000) Cancer Epidemiol. Biomarkers Prev., 9, 827–833.
Jourenkova, N., Reimkanen, M., Bouchardy, C., Husgafvel-Pursiamen, K., Dayer, P., Benhamou, S., and Hirvonen, A. (1997) Pharmacogenetics, 7, 515–518.
Jourenkova, N., Reimkainen, M., Bouchardy, C., Dayer, P., Benhamou, S., and Hirvonen, A. (1998) Cancer Epidemiol. Biomarkers Prev., 7, 19–23.
Hashibe, M., Brennan, P., Strange, R. C., Bhisey, R., et al. (2003) Cancer Epidemiol. Biomarkers Prev., 12, 1509–1517.
Hung, R. J., Boffetta, P., Brennan, P., Malaveille, C., Hautefeuille, A., Donate, F., Gelatti, U., Spaliviero, M., Placidi, D., Carta, A., Scotto di Carlo, A., and Porru, S. (2004) Int. J. Cancer, 110, 598–604.
Kocabas, N. A., Sardas, S., Cholerton, S., Daly, A. K., and Karakaya, A. E. (2002) Arch. Toxicol., 76, 643–649.
Sasaki, M., Tanaka, Y., Kaneuchi, M., Sakuragi, N., and Dahiya, R. (2003) Cancer Res., 63, 3913–3918.
IARC Monographs of the Evaluation of Carcinogenic Risk to Humans “Tobacco Smoke and Involuntary Smoking” (2004) Lyon, France, Vol. 83.
IARC Monographs of the Evaluation of Carcinogenic Risk to Humans “Alcohol Drinking” (1988) Lyon, France, Vol. 83.
Hashibe, M., Boffetta, P., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Mates, D., Janout, V., Fabidnovi, E., Bencko, V., Moullan, N., Chabrier, A., Hung, R., Hall, J., Canzian, F., and Brennan, P. (2006) Cancer Epidemiol. Biomarkers Prev., 15, 696–703.
Brennan, P., Hsu, C. C., Moullan, N., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Gemignani, F., Chabrier, A., Hall, J., Hung, R. J., Boffetta, P., and Canzian, F. (2005) Lancet, 366, 1558–1560.
Moore, L. E., Brennan, P., Karami, S., Hung, R. J., Hsu, C., Boffetta, P., Toro, J., Zaridze, D., Janout, V., Bencko, V., Navratilova, M., Szeszenia-Dabrowska, N., Mates, D., Mukeria, A., Holcatova, I., Welch, R., Chanock, S., Rothman, N., and Chow, W. H. (2007) Carcinogenesis, 28, 1960–1964.
Cohet, C., Borel, S., Nyberg, F., Mukeria, A., Bruske-Hohlfeld, I., Constantinescu, V., Benhamou, S., Brennan, P., Hall, J., and Boffetta, P. (2004) Cancer Epidemiol. Biomarkers Prev., 13, 320–323.
Hung, R. J., Brennan, P., Canzian, F., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Chabrier, A., Borel, S., Hall, J., and Boffetta, P. (2005) J. Natl. Cancer Inst., 97, 567–576.
Sugimura, H., Kohno, T., Wakai, K., Nagura, K., Genka, K., Igarashi, H., et al. (1999) Cancer Epidemiol. Biomarkers Prev., 8, 669–674.
Le Marchand, L., Donlon, T., Lum-Jones, A., Seifried, A., and Wilkens, L. R. (2002) Cancer Epidemiol. Biomarkers Prev., 11, 409–412.
Wikman, H., Risch, A., Klimek, F., Schmezer, P., Spiegelhalder, B., Dienemann, H., et al. (2000) Int. J. Cancer, 88, 932–937.
Ito, H., Hamajima, N., Takezaki, T., Matsuo, K., Tajima, K., Hatooka, S., et al. (2002) J. Epidemiol., 12, 258–265.
Landi, S., Gemignani, F., Canzian, F., Gaborieau, V., Barale, R., Landi, D., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Gioia-Patricola, L., Hall, J., Boffetta, P., Hung, R. J., and Brennan, P. (2006) Cancer Res., 66, 11062–11069.
Zaridze, D., Borisova, E., Maximovitch, D., and Chkhikvadze, V. (1999) Int. J. Cancer, 82, 473–476.
Thun, M. J., Henley, J., and Patrono, C. (2002) J. Natl. Cancer Inst., 94, 252–263.
El-Omar, E. M., Carrington, M., Chow, W.-H., McColl, E. E. L., Bream, J. H., Young, H. A., et al. (2002) Nature, 404, 398–402.
El-Omar, E. M., Rabkin, C. S., Gammon, M. D., Vaughan, T. L., Risch, H. A., Schroenberg, J. B., et al. (2003) Gastroenterology, 124, 1193–1201.
Taguchi, A., Ohmiya, N., Shirai, K., Mabuchi, N., Itoh, A., Hirooka, Y., Niwa, Y., and Goto, H. (2005) Cancer Epidemiol. Biomarkers Prev., 14, 2487–2493.
Campa, D., Hashibe, M., Zaridze, D., Szeszenia-Dabrowska, N., Mates, I. N., Janout, V., Holcatova, I., Fabianova, E., Gaborieau, V., Hung, R. J., Boffetta, P., Brennan, P., and Canzian, F. (2007) Cancer Causes Control, 18, 449–455.
Martinez, M. E., O’Brien, T. G., Fultz, K. E., Babbar, N., Yerushalmi, H., Qu, N., Guo, Y., Boorman, D., et al. (2003) Proc. Natl. Acad. Sci. USA, 100, 7859–7864.
Brennan, P., McKay, J., Moore, L., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Chow, W.-H., Rothman, N., Chabrier, A., Gaborieau, V., Timpson, N., Hung, R., and Smith, G. D. (2008) Am. J. Epidemiol., in press.
Hung, R. J., Hashibe, M., McKay, J., Gaborieau, V., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Mates, I., Foretova, L., Janoyt, V., Bencko, V., Chabrier, A., Moullan, N., Canzian, F., Hall, J., Boffetta, P., and Brennan, P. (2007) Carcinogenesis, 28, 1334–1340.
Brennan, P., McKay, J., Moore, L., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Chow, W.-H., Rothman, N., Chabrier, A., Gaborieau, V., Odefrey, F., Southey, M., Hashibe, M., Hall, J., Boffetta, P., Peto, R., and Hung, R. J. (2007) Hum. Mol. Genet., 16, 1794–1801.
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Original Russian Text © D. G. Zaridze, 2008, published in Biokhimiya, 2008, Vol. 73, No. 5, pp. 661–674.
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Zaridze, D.G. Molecular epidemiology of cancer. Biochemistry Moscow 73, 532–542 (2008). https://doi.org/10.1134/S0006297908050064
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DOI: https://doi.org/10.1134/S0006297908050064