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Papillomaviruses—to vaccination and beyond

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Abstract

High risk human papillomavirus (HPV) types 16 and 18 DNAs were initially identified in 1983–1984. Subsequently the DNA of several other high risk HPV types has been identified. HPV 16 is present in more than 50% of cervical cancer biopsies, and HPV 18 is close to 20%. Some geographic variations exist in the prevalence of HPV high risk types: e.g. HPV 45 is more frequently observed in equatorial Africa, whereas types 58 and 52 have been more often found in East Asia. Molecular as well as epidemiological studies demonstrate that high risk HPV are indeed the causative agents for cervical cancer, they are also involved in other anogenital cancers, and in 25–30% of oropharyngeal carcinomas. Some of the mechanistic aspects are discussed in this review.

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Abbreviations

HPV:

human papillomavirus

LSIL, HSIL:

low and high grade squamous intraepithelial lesions, respectively

VLP:

virus-like particles

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Authors and Affiliations

  1. Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    H. zur Hausen

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  1. H. zur Hausen
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Correspondence to H. zur Hausen.

Additional information

This manuscript is dedicated to Professor Gary I. Abelev for his pioneering studies opening the field of cancer biomarkers

Published in Russian in Biokhimiya, 2008, Vol. 73, No. 5, pp. 619–626.

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zur Hausen, H. Papillomaviruses—to vaccination and beyond. Biochemistry Moscow 73, 498–503 (2008). https://doi.org/10.1134/S0006297908050027

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  • DOI: https://doi.org/10.1134/S0006297908050027

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