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Experimental testing of the role of cytoskeleton in the solution by neurons of problems facing the brain

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Abstract

Investigation of the influence of cAMP on neuronal electric activity suggests that nerve cells can solve problems using an intraneuronal calculating medium based on the cytoskeleton. When a new problem is posed, this structure has to be disassembled and assembled by the neuronal molecular computer according to the program recorded in DNA. If DNA lacks an appropriate program, the cytoskeleton will not be assembled. In our experiments, fishes which were rotated simultaneously around two mutually perpendicular axes lost their swimming ability, and some dramatic changes were observed in the cytoskeleton of their Mauthner neurons. These changes disappeared after a long-term rest: the cytoskeleton was restored simultaneously with the ability for normal swimming.

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Abbreviations

MC:

molecular computer

MN:

Mauthner neurons of fishes

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Authors and Affiliations

  1. Institute of Information Transmission Problems, Russian Academy of Sciences, B. Karetnyi Pereulok 19, 101447, Moscow, Russia

    E. A. Liberman & S. V. Minina

  2. Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia

    D. A. Moshkov & I. M. Santalova

  3. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, 119991, Moscow, Russia

    I. A. Chistopolskiy

  4. Hematology Research Center, Russian Academy of Medical Sciences, Novozykovskii pr. 4a, 125167, Moscow, Russia

    N. E. Shklovski-Kordi

Authors
  1. E. A. Liberman
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  2. S. V. Minina
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  3. D. A. Moshkov
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  4. I. M. Santalova
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  5. I. A. Chistopolskiy
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  6. N. E. Shklovski-Kordi
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Corresponding author

Correspondence to N. E. Shklovski-Kordi.

Additional information

Original Russian Text © E. A. Liberman, S. V. Minina, D. A. Moshkov, I. M. Santalova, I. A. Chistopolskiy, N. E. Shklovski-Kordi, 2008, published in Biokhimiya, 2008, Vol. 73, No. 4, pp. 587–591.

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Liberman, E.A., Minina, S.V., Moshkov, D.A. et al. Experimental testing of the role of cytoskeleton in the solution by neurons of problems facing the brain. Biochemistry Moscow 73, 479–482 (2008). https://doi.org/10.1134/S0006297908040147

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  • DOI: https://doi.org/10.1134/S0006297908040147

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