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Biological activity of hemoprotein nitrosyl complexes

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Abstract

Chemical and biological functions of hemoprotein nitrosyl complexes as well as their photolysis products are discussed in this review. Chemical properties of nitric oxide are discussed, and major chemical reactions such as interaction with thiols, free radicals, and transition metals are considered. Specific attention is paid to the generation of hemoprotein nitrosyl complexes. The mechanisms of nitric oxide reactions with hemoglobin and cytochrome c and physicochemical properties of their nitrosyl complexes are discussed. A review of photochemical reactions of nitrosyl complexes with various ligands is given. Finally, we observe physiological effects of visible radiation on hemoprotein nitrosyl complexes: smooth muscle relaxation and reactivation of mitochondrial respiration.

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Abbreviations

cGMP:

cycloGMP

cNOS:

constitutive isoform of NO-synthase

cyt a 2+3 -NO:

nitrosocytochrome a 3 reduced

cyt a 3+3 -NO:

nitrosocytochrome a 3 oxidized

cyt c 2+ :

reduced cytochrome c

cyt c 2+-NO:

reduced nitrosocytochrome c

cyt c 3+ :

oxidized cytochrome c

cyt c 3+-NO:

oxidized nitrosocytochrome c

deoxyHb:

deoxyhemoglobin

DETA-NONOate:

a compound releasing free NO upon decomposition

DNIC:

dinitrosyl iron complexes

EDRF:

endothelium-derived relaxing factor

EPR:

electron paramagnetic resonance

Hb:

hemoglobin

Hb(I)*, Hb(II)*:

hemoglobin excited states

Hb-4FeIV=O:

ferryl hemoglobin

Hb4NO:

nitrosyl hemoglobin

Hb4O2 :

oxyhemoglobin

HbCO:

carboxyhemoglobin

HbNO:

nitrosyl hemoglobin

HbO2 :

oxyhemoglobin

Hb-SNO:

S-nitrosohemoglobin

heme-Fe2+ :

heme containing Fe2+

heme-Fe2+-NO:

nitrosyl heme

HFS:

hyperfine structure

iNOS:

inducible isoform of NO-synthase

IP6 :

hexainositol phosphate

LPS:

lipopolysaccharides

Mb-FeIV=O:

ferryl myoglobin

metHb:

methemoglobin

metMb:

metmyoglobin

mtNOS:

mitochondrial isoform of NO-synthase

NO:

nitric oxide

NO− :

nitroxyl-anion

NO+ :

nitrosonium-cation

NO2 :

nitrogen dioxide radical

NO −2 :

nitrite

NO −3 :

nitrate

OH:

hydroxyl radical

O −2 :

superoxide radical

ONOO− :

peroxynitrite anion

RSH(RS−):

thiols (protonated/deprotonated form)

RS-NO:

nitrosothiols

TNF:

tumor necrosis factor

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Authors and Affiliations

  1. Russian State Medical University, ul. Ostrovityanova 1, 117997, Moscow, Russia

    A. N. Osipov

  2. Research Institute for Physical and Chemical Medicine, Malaya Pirogovskaya ul. 1a, 119992, Moscow, Russia

    G. G. Borisenko

  3. Faculty of Basic Medicine, Lomonosov Moscow State University, Lomonosovsky pr. 31/5, 119192, Moscow, Russia

    Yu. A. Vladimirov

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  1. A. N. Osipov
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  2. G. G. Borisenko
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  3. Yu. A. Vladimirov
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Correspondence to A. N. Osipov.

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Original Russian Text © A. N. Osipov, G. G. Borisenko, Yu. A. Vladimirov, 2007, published in Uspekhi Biologicheskoi Khimii, 2007, Vol. 47, pp. 259–292.

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Osipov, A.N., Borisenko, G.G. & Vladimirov, Y.A. Biological activity of hemoprotein nitrosyl complexes. Biochemistry Moscow 72, 1491–1504 (2007). https://doi.org/10.1134/S0006297907130068

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