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DNA mimicry by proteins as effective mechanism for regulation of activity of DNA-dependent enzymes

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Abstract

Modern concepts on mechanisms of DNA-dependent enzyme regulation involving specific DNA-mimicking proteins are considered. There are proteins that share structural resemblance with DNA duplexes. These include inhibitors of type I restriction-modification enzymes (Ocr and ArdA), inhibitors of DNA gyrase MfpA and QnrABS, etc. We describe here structural features of these proteins and mechanisms responsible for their interaction with DNA-dependent enzymes and then discuss perspectives of use of DNA-mimicking proteins in analysis of replication, repair, recombination, mechanisms underlying resistance to antibiotics, and also fields of applied biotechnology.

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Abbreviations

PRP:

pentapeptide repeat proteins

Rfr:

repeated five-residues

UDG:

uracil-DNA glycosylases

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Authors and Affiliations

  1. State Research Institute of Genetics and Selection of Industrial Microorganisms, 1-yi Dorozhnyi Proezd 1, 117545, Moscow, Russia

    G. B. Zavilgelsky & S. M. Rastorguev

Authors
  1. G. B. Zavilgelsky
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  2. S. M. Rastorguev
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Correspondence to G. B. Zavilgelsky.

Additional information

Original Russian Text © G. B. Zavilgelsky, S. M. Rastorguev, 2007, published in Biokhimiya, 2007, Vol. 72, No. 9, pp. 1125–1132.

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Zavilgelsky, G.B., Rastorguev, S.M. DNA mimicry by proteins as effective mechanism for regulation of activity of DNA-dependent enzymes. Biochemistry Moscow 72, 913–919 (2007). https://doi.org/10.1134/S0006297907090015

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  • DOI: https://doi.org/10.1134/S0006297907090015

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