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Revision of the antigen receptor of T-lymphocytes

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Abstract

This review considers a crucially new mechanism of T-cell antigen-recognizing repertoire formation. It includes the revision of T-cell antigen receptor (TCR), which implies the secondary rearrangement of TCR genes in peripheral T-lymphocytes and surface expression of a new antigen receptor with altered specificity. Factors and mechanisms involved in the induction of this process have been analyzed. Certain attention is paid to a possible role of TCR revision in the formation of peripheral tolerance in the processes of “avidity maturation” of T-lymphocytes during immune response and also negative consequences related to appearance of potentially autoreactive clones in the periphery.

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Abbreviations

CD:

clusters of differentiation

MBP:

myelin basic protein

Mtv:

mammary tumor virus

NOD:

non-obese diabetic (mice)

RAG:

recombination activating genes

RSS:

recombination signal sequence

TCR:

T-cell receptor

TdT:

terminal deoxyribonucleotide transferase

References

  1. Yarilin, A. A., Pinchuk, V. G., and Grinevich, Yu. A. (1991) Structure of Thymus and Differentiation of T-Lymphocytes [in Russian], Naukova Dumka, Kiev.

    Google Scholar 

  2. Fehling, H. J., and von Boehmer, H. (1997) Curr. Opin. Immunol., 9, 263–275.

    Article  PubMed  CAS  Google Scholar 

  3. McMahan, C. J., and Fink, P. J. (1998) Immunity, 9, 637–647.

    Article  PubMed  CAS  Google Scholar 

  4. Huang, C.-Y., Golub, R., Gillian, E. W., and Kanagawa, O. (2002) J. Immunol., 168, 3259–3265.

    PubMed  CAS  Google Scholar 

  5. Serra, P., Amrani, A., Han, B., Yamanouchi, J., Thiessen, S. J., and Santamaria, P. (2002) Proc. Natl. Acad. Sci. USA, 99, 15566–15571.

    Article  PubMed  CAS  Google Scholar 

  6. Tonegawa, S. (1983) Nature, 302, 575–581.

    Article  PubMed  CAS  Google Scholar 

  7. Lewis, S. M. (1994) Adv. Immunol., 56, 27–150.

    Article  PubMed  CAS  Google Scholar 

  8. Schatz, D. G., Oettinger, M. A., and Baltimore, D. (1989) Cell, 59, 1035–1048.

    Article  PubMed  CAS  Google Scholar 

  9. Oettinger, M. A., Schatz, D. G., Gorka, C., and Baltimore, D. (1990) Science, 248, 1517–1523.

    PubMed  CAS  Google Scholar 

  10. Van Gent, D. C., McBlane, J. F., Ramsden, D. A., Sadofsky, M. J., Hesse, J. E., and Gellert, M. (1995) Cell, 81, 925–934.

    Article  PubMed  Google Scholar 

  11. Gellert, M. (2002) Annu. Rev. Biochem., 71, 101–132.

    Article  PubMed  CAS  Google Scholar 

  12. Bassing, C. H., Swat, W., and Alt, F. W. (2002) Cell, 109, 545–555.

    Article  Google Scholar 

  13. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., and Papaioannju, V. E. (1992) Cell, 68, 869–877.

    Article  PubMed  CAS  Google Scholar 

  14. Shinkai, Y., Rathbun, G., Kong-Peng, L., Oltz, E. V., Srewart, V., Mendelsohn, M., Sharron, J., Datta, M., Yong, F., Stall, A. M., and Alt, F. W. (1992) Cell, 68, 855–867.

    Article  PubMed  CAS  Google Scholar 

  15. Turka, L., Schatz, D., Oettinger, M., Chun, J., Gorka, C., Lee, K., McCormack, W., and Thompson, C. (1991) Science, 16, 778–781.

    Google Scholar 

  16. Van Gent, D. C., Ramsden, D. A., and Gellert, M. (1996) Cell, 85, 107–113.

    Article  PubMed  Google Scholar 

  17. Fugmann, S. D., Lee, A. I., Shockett, P. E., Villey, I. J., and Schatz, D. G. (2000) Annu. Rev. Immunol., 18, 495–527.

    Article  PubMed  CAS  Google Scholar 

  18. Difilippantonio, M. J., McMahan, C. J., Eastman, Q. M., Spanopoulou, E., and Schatz, D. G. (1996) Cell, 87, 253–262.

    Article  PubMed  CAS  Google Scholar 

  19. Akamatsu, Y., and Oettinger, M. A. (1998) Mol. Cell Biol., 18, 4670–4678.

    PubMed  CAS  Google Scholar 

  20. Fugmann, S. D., and Schatz, D. G. (2001) Mol. Cell, 8, 899–910.

    Article  PubMed  CAS  Google Scholar 

  21. Mo, X., Bailin, T., and Sadofsky, M. (1999) J. Biol. Chem., 274, 7025–7031.

    Article  PubMed  CAS  Google Scholar 

  22. Swanson, P. C., and Desiderio, S. (1999) Mol. Cell Biol., 19, 3674–3683.

    PubMed  CAS  Google Scholar 

  23. Bailin, T., Mo, X., and Sadofsky, M. J. (1999) Mol. Cell Biol., 19, 4664–4671.

    PubMed  CAS  Google Scholar 

  24. Mundy, C. L., Patenge, N., Matthews, A. G. W., and Oettinger, M. A. (2002) Mol. Cell Biol., 22, 69–77.

    Article  PubMed  CAS  Google Scholar 

  25. Lauring, J., and Schlissel, M. S. (1999) Mol. Cell Biol., 19, 2601–2612.

    PubMed  CAS  Google Scholar 

  26. McBlane, J. F., van Gent, D. C., Ramsden, D. A., Romeo, C., Cuomo, C. A., Gellert, M., and Oettinger, M. A. (1995) Cell, 83, 387–395.

    Article  PubMed  CAS  Google Scholar 

  27. Eastman, Q. M., Leu, T. M., and Schatz, D. G. (1996) Nature, 380, 85–88.

    Article  PubMed  CAS  Google Scholar 

  28. Hiom, K., and Gellert, M. (1997) Cell, 88, 65–72.

    Article  PubMed  CAS  Google Scholar 

  29. Tsai, C.-L., Drejer, A. H., and Schatz, D. G. (2002) Genes Dev., 16, 1934–1949.

    Article  PubMed  CAS  Google Scholar 

  30. Shockett, P. E., and Schatz, D. G. (1999) Mol. Cell Biol., 19, 4159–4166.

    PubMed  CAS  Google Scholar 

  31. Ramsden, D. A., Paull, T. T., and Gellert, M. (1997) Nature, 388, 488–491.

    Article  PubMed  CAS  Google Scholar 

  32. Wilson, A., Held, W., and MacDonald, H. R. (1994) J. Exp. Med., 179, 1355–1360.

    Article  PubMed  CAS  Google Scholar 

  33. Lin, W. C., and Desiderio, S. (1994) Proc. Natl. Acad. Sci. USA, 91, 2733–2737.

    Article  PubMed  CAS  Google Scholar 

  34. Monroe, R., Seidl, K., Gaertner, F., Han, S., Chen, F., Sekiguchi, J., Wang, J., Ferrini, R., Davidson, L., Kelsoe, G., and Alt, F. (1999) Immunity, 11, 201–212.

    Article  PubMed  CAS  Google Scholar 

  35. Yu, W., Nagaoka, H., Jankovic, M., Misulovin, Z., Suh, H., Rolink, A., Melchers, F., Meffre, E., and Nussenzweig, M. C. (1999) Nature, 400, 682–687.

    Article  PubMed  CAS  Google Scholar 

  36. McMahan, C. J., and Fink, P. J. (2000) J. Immunol., 165, 6902–6907.

    PubMed  CAS  Google Scholar 

  37. Ali, M., Weireich, M., Balcaitis, S., Cooper, C. J., and Fink, P. J. (2003) J. Immunol., 171, 6290–6296.

    PubMed  CAS  Google Scholar 

  38. Cooper, C. J., Orr, M. T., McMahan, C. J., and Fink, P. J. (2003) J. Immunol., 171, 226–233.

    PubMed  CAS  Google Scholar 

  39. Scherer, M. T., Ignatovicz, L., Pullen, A., Kappler, J., and Marrack, P. (1995) J. Exp. Med., 182, 1493–1504.

    Article  PubMed  CAS  Google Scholar 

  40. Fink, P. J., Fang, C. A., and Turk, G. L. (1994) J. Immunol., 152, 4270–4281.

    PubMed  CAS  Google Scholar 

  41. Fink, P. J., Swan, K., Turk, G., Moore, M. W., and Carbone, F. R. (1992) J. Exp. Med., 176, 1733–1738.

    Article  PubMed  CAS  Google Scholar 

  42. Bynoe, M. C., Viret, C., Flawell, R. A., and Janeway, C. A., Jr. (2005) Proc. Natl. Acad. Sci. USA, 102, 2898–2903.

    Article  PubMed  CAS  Google Scholar 

  43. Lantelme, E., Palermo, B., Granziero, L., Mantovani, S., Campanelli, R., Monafo, V., Lanzavecchia, A., and Giachino, C. (2000) J. Immunol., 164, 3455–3459.

    PubMed  CAS  Google Scholar 

  44. Kyoizumi, S., Akiyama, M., Hirai, Y., Kusunoki, Y., Tanabe, K., and Umeki, S. (1990) J. Exp. Med., 171, 1981–1999.

    Article  PubMed  CAS  Google Scholar 

  45. Vaitaitis, G. M., Poulin, M., Sanderson, M. J., Haskins, K., and Wagner, D. H., Jr. (2003) J. Immunol., 170, 3455–3459.

    PubMed  CAS  Google Scholar 

  46. Kondo, E., Wakao, H., Koseki, H., Takemori, T., Kojo, S., Harada, M., Takahashi, M., Sakata, S., Shimizu, C., Nakayama, T., and Taniguchi, M. (2003) Int. Immunol., 15, 393–402.

    Article  PubMed  CAS  Google Scholar 

  47. Collins, C., Norris, S., McEntee, G., Traynor, O., Bruno, L., von Boehmer, H., Hegarty, G., and O’Farrelly, C. (1996) Eur. J. Immunol., 26, 3114–3118.

    PubMed  CAS  Google Scholar 

  48. Rocha, B., Vassalli, P., and Guy-Grand, D. (1991) J. Exp. Med., 173, 483–486.

    Article  PubMed  CAS  Google Scholar 

  49. Bas, A., Hammarstrom, S. G., and Hammarstrom, M.-L. K. C. (2003) J. Immunol., 171, 3359–3371.

    PubMed  CAS  Google Scholar 

  50. Huang, C. Y., Sleckman, B. P., and Kanagawa, O. (2005) Proc. Natl. Acad. Sci. USA, 102, 14356–14361.

    Article  PubMed  CAS  Google Scholar 

  51. Petrie, H. T., Livak, F., Schatz, D. G., Strasser, A., Crispe, I. N., and Shortman, K. (1993) J. Exp. Med., 178, 615–622.

    Article  PubMed  CAS  Google Scholar 

  52. Hearth, W. R., Carbone, F. R., Bertolino, P., Kelly, J., Cose, S., and Miller, J. F. (1995) Eur. J. Immunol., 25, 1617–1623.

    Google Scholar 

  53. Davodeau, F., Difilippantonio, M., Roldan, E., Malissen, M., Casanova, J. L., Couedel, C., Morcet, J. F., Merkenschlager, M., Nussenzweig, A., Bonneville, M., and Malissen, B. (2001) EMBO J., 20, 4717–4729.

    Article  PubMed  CAS  Google Scholar 

  54. Alam, S. M., Crispe, I. N., and Gascoigne, N. R. (1995) Immunity, 3, 449–458.

    Article  PubMed  CAS  Google Scholar 

  55. Nemazee, D., and Hogquist, K. A. (2003) Curr. Opin. Immunol., 15, 182–189.

    Article  PubMed  CAS  Google Scholar 

  56. Ferguson, S. E., Han, S., Kelsoe, G., and Thompson, C. B. (1996) J. Immunol., 156, 4576–4581.

    PubMed  CAS  Google Scholar 

  57. Manser, T., Tumas-Brundage, K. M., Casson, L. P., Giusti, A. M., Hande, S., Notidis, E., and Vora, K. A. (1998) Immunol. Rev., 162, 183–196.

    Article  PubMed  CAS  Google Scholar 

  58. Cooper, C. J., Turk, G. L., Sun, M., Farr, A. G., and Fink, P. J. (2004) J. Immunol., 173, 6532–6536.

    PubMed  CAS  Google Scholar 

  59. Wagner, D. H., Jr., Newell, T., Sanderson, R. J., Freed, J. H., and Newell, M. K. (1999) Int. J. Mol. Med., 4, 231–242.

    PubMed  CAS  Google Scholar 

  60. Waid, D. M., Vaitaitis, G. M., and Wagner, D. H., Jr. (2004) Eur. J. Immunol., 34, 1488–1497.

    Article  PubMed  CAS  Google Scholar 

  61. Berberich, I., Shu, G. L., and Clark, E. A. (1994) J. Immunol., 153, 4357–4366.

    PubMed  CAS  Google Scholar 

  62. Grewal, I. S., and Flawell, R. A. (1998) Annu. Rev. Immunol., 16, 111–135.

    Article  PubMed  CAS  Google Scholar 

  63. Rammensee, H. G., Kroschewski, R., and Frangoulis, B. (1989) Nature, 339, 541–544.

    Article  PubMed  CAS  Google Scholar 

  64. Ramsdell, F., and Fowlkes, B. J. (1992) Science, 257, 1130–1134.

    PubMed  CAS  Google Scholar 

  65. Kawabe, Y., and Ochi, A. (1991) Nature, 349, 245–248.

    Article  PubMed  CAS  Google Scholar 

  66. Alferink, J., Tafuri, A., Klevenz, A., Hammerling, G. J., and Arnold, B. (1998) Novartis Found. Symp., 215, 191–196.

    PubMed  CAS  Google Scholar 

  67. Oh, S., Perera, L. P., Burke, D. S., Waldmann, T. A., and Berzofsky, J. A. (2004) Proc. Natl. Acad. Sci. USA, 101, 15154–15159.

    Article  PubMed  CAS  Google Scholar 

  68. Slifka, M. K., and Whitton, J. L. (2001) Nat. Immunol., 2, 711–717.

    Article  PubMed  CAS  Google Scholar 

  69. Lantelmi, E., Turinetto, V., Mantovani, S., Marchi, A., Regazzoni, S., Porcedda, P., de Marchi, M., and Giachino, C. (2003) Lab. Invest., 83, 1467–1475.

    Article  Google Scholar 

  70. Hikida, M., Mori, M., Takai, T., Tomochika, K.-I., Hamatani, K., and Ohmori, H. (1996) Science, 274, 2092–2094.

    Article  PubMed  CAS  Google Scholar 

  71. Han, S., Dillion, S. R., Zheng, B., Shimoda, M., Schlissel, M. S., and Kelsoe, G. (1997) Science, 278, 301–305.

    Article  PubMed  CAS  Google Scholar 

  72. Papavasiliou, F., Casellas, R., Suh, H., Qin, X. F., Besmer, E., Pelanda, R., Nemazee, D., Rajewski, K., and Nussenzweig, M. C. (1997) Science, 278, 298–301.

    Article  PubMed  CAS  Google Scholar 

  73. Kuwata, N., Igarashi, H., Ohmura, T., Aizawa, S., and Sakaguchi, N. (1999) J. Immunol., 163, 6355–6359.

    PubMed  CAS  Google Scholar 

  74. Gartner, F., Alt, F. W., Monroe, R. J., and Seidl, K. J. (2000) J. Exp. Med., 192, 1745–1754.

    Article  PubMed  CAS  Google Scholar 

  75. Vanderlugt, C. L., Begolka, W. S., Neville, K. L., Katz-Levy, Y., Howard, L. M., Eagar, T. N., Bluestone, J. A., and Miller, S. D. (1998) Immunol. Rev., 164, 63–72.

    Article  PubMed  CAS  Google Scholar 

  76. Olson, J. K., Croxford, J. L., Calenoff, M. A., dal Canto, M. C., and Miller, S. D. (2001) J. Clin. Invest., 108, 311–318.

    Article  PubMed  CAS  Google Scholar 

  77. Ray, S. K., Putterman, C., and Diamond, B. (1996) Proc. Natl. Acad. Sci. USA, 93, 2019–2024.

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, ul. Goleva 13, 614081, Perm, Russia

    E. M. Kuklina

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Original Russian Text © E. M. Kuklina, 2006, published in Biokhimiya, 2006, Vol. 71, No. 8, pp. 1021–1033.

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Kuklina, E.M. Revision of the antigen receptor of T-lymphocytes. Biochemistry (Moscow) 71, 827–837 (2006). https://doi.org/10.1134/S0006297906080025

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