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Protein kinase Cζ and glucose uptake

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Abstract

Protein kinase Cζ (PKCζ) is a member of the PKC family, serving downstream of insulin receptor and phosphatidylinositol (PI) 3-kinase. Many evidences suggest that PKCζ plays a very important role in activating glucose transport response. Not only insulin but also glucose and exercise can activate PKCζ through diverse pathways. PKCζ activation and activity are impaired with insulin resistance in muscle and adipose tissues of type II diabetes individuals, but heightened in liver tissue, wherein it also increases lipid synthesis mediated by SREBP-1c (sterol-regulatory element-binding protein). Many studies have focused on linkage between PKCζ and GLUT4 translocation and activation. Exploring the molecular mechanisms and pathways by which PKCζ mediates glucose transport will highlight the insulin-signaling pathway.

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Abbreviations

DAG:

diacylglycerol

GEF:

GLUT4-activating factor

IRS:

insulin receptor substrate

PI:

phosphatidylinositol

PI3K:

phosphatidylinositol-3-kinase

PDK-1:

PI3-kinase-dependent protein kinase-1

PIP3 :

phosphatidylinositol-3,4,5-triphosphate

PKCζ:

protein kinase Cζ

PKB:

protein kinase B

aPKC:

atypical protein kinase C

PH:

pleckstrin homology

PS:

pseudosubstrate

VAMP-2:

vesicle-associated membrane protein-2

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Authors and Affiliations

  1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China

    Li-Zhong Liu, Ai-Bin He, Xiao-Jun Liu, Yi Li, Yong-Sheng Chang & Fu-De Fang

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  1. Li-Zhong Liu
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  2. Ai-Bin He
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  3. Xiao-Jun Liu
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  4. Yi Li
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Correspondence to Fu-De Fang.

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Published in Russian in Biokhimiya, 2006, Vol. 71, No. 7, pp. 869–875.

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Liu, LZ., He, AB., Liu, XJ. et al. Protein kinase Cζ and glucose uptake. Biochemistry (Moscow) 71, 701–706 (2006). https://doi.org/10.1134/S0006297906070017

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  • DOI: https://doi.org/10.1134/S0006297906070017

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