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Prospects for the Development of Anti-Influenza Drugs Based on Medicinal Mushrooms (Review)

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Abstract

Russian and international publications on the antiviral activity of medicinal mushrooms against influenza, which have been studied in cell culture and animal models, on the presence of sialidase (neuraminidase) inhibitors and RNA polymerase inhibitors of influenza virus are considered. The activity against influenza of both aqueous extracts of higher fungi and the polysaccharides, peptidoglycans, proteins, melanin, polyphenols, and terpenoids present in them is described. It is noted that further studies of the antiviral mechanisms of these components of medicinal mushrooms, both those grown in natural conditions and those cultivated with solid-phase or submerged methods in laboratory and factory conditions, are required in order to develop drugs based on them.

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Funding

This work was carried out according to the State Task on the topic “Development of prophylactic and medicinal drugs based on basidiomycetes for the treatment and prevention of influenza with pandemic potential (2017–2020),” within the Research Program of Rospotrebnadzor for 2016–2020.

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Authors and Affiliations

  1. State Research Center of Virology and Biotechnology “Vector”, 630559, Koltsovo, Novosibirsk oblast, Russia

    T. V. Teplyakova, T. N. Ilyicheva & N. A. Markovich

  2. Novosibirsk State University, 630090, Novosibirsk, Russia

    T. N. Ilyicheva

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  1. T. V. Teplyakova
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  2. T. N. Ilyicheva
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  3. N. A. Markovich
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Correspondence to T. V. Teplyakova or N. A. Markovich.

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Translated by D. Novikova

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Teplyakova, T.V., Ilyicheva, T.N. & Markovich, N.A. Prospects for the Development of Anti-Influenza Drugs Based on Medicinal Mushrooms (Review). Appl Biochem Microbiol 56, 489–496 (2020). https://doi.org/10.1134/S0003683820050142

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