Antimicrobic Activity of the Lipopeptide Emericellipsin A Isolated from Emericellopsis alkalina against Biofilm-Forming Bacteria

Abstract

The antimicrobial activity of the new nonribosomal peptide emericellipsin A against biofilm-forming, pathogenic, gram-positive and gram-negative clinical bacteria was studied. It was shown for the first time that peptides from the group of peptaibols can inhibit pathogenic forms of bacteria via their effect on biofilm formation. The most pronounced effect was demonstrated in relation to gram-positive bacteria.

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ACKNOWLEDGMENTS

The authors are grateful to the staff of the Department of Microbiology and Infectious Diseases of the Orenburg State Agrarian University and personally to M.V. Sycheva for her assistance with the study of the antimicrobial properties of emericellipsin A.

Funding

The work on the isolation and accumulation of emericellipsin A for biological testing was carried out with the financial support of the Russian Science Foundation (grant no. 18-74-10073), and the producer was cultivated the financial support of the Russian Federal Property Fund in the framework of scientific project no. 19-34-90088.

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Correspondence to V. S. Sadykova.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Sadykova, V.S., Gavryushina, I.A., Kuvarina, A.E. et al. Antimicrobic Activity of the Lipopeptide Emericellipsin A Isolated from Emericellopsis alkalina against Biofilm-Forming Bacteria. Appl Biochem Microbiol 56, 292–297 (2020). https://doi.org/10.1134/S0003683820030102

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Keywords:

  • biofilm-forming bacteria
  • antimicrobial peptides
  • emericellipsin A
  • alkaliphilic fungi
  • inhibition of formation biofilm