Abstract
The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.
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REFERENCES
Klimko, N., Kozlova, Y., Khostelidi, S., Shadri-vova, O., Borzov, Y., Burygina, E., Vasilieva, N., and Denning, D.W., Mycoses, 2015, vol. 58, suppl. S5, pp. 58–62.
Pegorie, M., Denning, D.W., and Welfare, W., J. Infect., 2017, vol. 74, no. 1, pp. 60–71.
Gessmann, R., Axford, D., Bruckner, H., Berg, A., and Petratos, K., Acta Crystallogr., 2017, vol. 73, no. 2, pp. 95–100.
Overy, D.P., Bayman, P., Kerr, R.G., and Bills, G.F., Mycology, 2014, vol. 5, no. 3, pp. 145–167.
Georgieva, M.L., Tolstykh, I.V., Bilanenko, E.N., and Katrukha, G.S., Mikol. Fitopatol., 2009, vol. 4, no. 6, pp. 84–91.
Baranova, A.A., Georgieva, M.L., Bilanenko, E.N., Andreev, Ya.A., Rogozhin, E.A., and Sadykova, V.S., Appl. Biochem. Microbiol., 2017, vol. 53, no. 6, pp. 703–710.
Grum-Grzhimaylo, A.A., Georgieva, M.L., Debets, A.J.M., and Bilanenko, E.N., IMA Fungus, 2013, vol. 4, no. 2, pp. 211–226.
Grum-Grzhimaylo, A.A., Georgieva, M.L., Bondarenko, S.A., Debets, A.J.M., and Bilanenko, E.N., Fungal Diversity, 2016, vol. 76, no. 1, pp. P. 27–74.
Balouiri, M., Sadiki, M., and Ibnsouda, S.K., J. Pharm. Anal., 2016, vol. 6, no. 2, pp. 71–79.
Overy, D., Correa, H., Roullier, C., Chi, W.-C., Pang, K.-L., Rateb, M., Ebel, R., Shang, Z., Capon, R., Bills, G., and Kerr, R., Mar. Drugs, 2017, vol. 15, no. 254, pp. 1–18.
Imhoff, J.F., Mar. Drugs, 2016, vol. 14, no. 19, pp. 1–19.
De Vries, R., Riley, R., Wiebenga, A., Aguilar-Osorio, G., Amillis, S., Uchima, C., Anderluh, G., Asadollahi, M., Askin, M., and Barry, K., Genome Biol., 2017, vol. 18, no. 1 (28), pp. 2–45.
Santos, I.M., Abrunhosa, L., Venancio, A., and Lima, N., Lett. Appl. Microbiol., 2002, vol. 35, no. 4, pp. 272–275.
Yue, Q., Chen, L., Zhang, X., Li, K., Sun, J., Liu, X., An, Z., and Bills, G.F., Eukaryot. Cell, 2015, vol. 14, no. 7, pp. 698–718.
Kulko, A.B., Oncohematology, 2012, vol. 7, no. 3, pp. 55–61.
Kul’ko, A.B., Kisil’, O.V., Sadykova, V.S. Mikhaylov, V.F., Vasil’eva, I.M., Shulenina, L.V., Zasukhina, G.D., and Rogozhin, E.A., Antibiot. Khimioter., 2016, vol. 61, nos. 9–10, pp. 8–16.
Duclohier, H., Chem. Biodivers., 2007, vol. 4, no. 6, pp. 1023–1026.
Leitgeb, B., Szekeres, A., Manczinger, L., Vágvölgyi, C., and Kredics, L., Chem Biodivers., 2007, vol. 4, no. 6, pp. 1027–1051.
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Baranova, A.A., Rogozhin, E.A., Georgieva, M.L. et al. Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina: Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi. Appl Biochem Microbiol 55, 145–151 (2019). https://doi.org/10.1134/S0003683819020030
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DOI: https://doi.org/10.1134/S0003683819020030