Skip to main content
SpringerLink
Log in

Antimicrobial Peptides in Health and Disease (Review)

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

The review describes the latest data on the role of antimicrobial peptides (AMPs) in health and disease, as well as their structure and mechanisms of action. AMPs mediate protection by both direct lysis of bacteria and also by regulation of inflammation and chemotaxis, thus demonstrating immunomodulatory properties. A large amount of data shows that AMPs play an important role in the pathogenesis of multiple chronic diseases with genetic predisposition, such as atopic dermatitis, rosacea, and scleroderma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Izadpanah, A. and Gallo, R.L., J. Am. Acad. Dermatol., 2005, vol. 52, no. 3, pp. 381–390.

    Article  PubMed  Google Scholar 

  2. Diamond, G., Beckloff, N., Weinberg, A., and Kisich, K.O., Curr. Pharm. Des., 2009, vol. 15, no. 21, pp. 2377–2392.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Kulakova, E.V and Elizarova, V.M., Pampura, A.N, Ross. Stomatol. Zh., 2012, no. 6, pp. 42–45.

    Google Scholar 

  4. Silva, F. and Machado, M.C.C., Peptides, 2012, vol. 36, no. 2, pp. 308–314.

    Article  CAS  Google Scholar 

  5. Budikhina, A.S. and Pinegin, B.V., Immunol. Allergol. Infektolog., 2008, no. 2, pp. 31–40.

    Google Scholar 

  6. Abaturov, A.E., Zdorov’e Rebenka, 2011, vol. 7, no. 34, pp. 161–170.

    Google Scholar 

  7. Marcinkiewicz, M. and Majewski, S., Adv. Dermatol. Allergol., 2016, vol. 1, no. 1, pp. 6–12.

    Article  Google Scholar 

  8. Zharkova, M.S., Orlov, D.S., Kokryakov, V.N., and Shamova, O.V., Vestnik SPbGU, 2014, no. 1, pp. 98–114.

    Google Scholar 

  9. Dudnikova, E.V. and Bad’yan, A.S., Med. Vestnik Yuga Rossii, 2014, no. 2, pp. 9–14.

    Google Scholar 

  10. Gallo, R.L., Ono, M., Povsict, T., Page, C., Eriksson, E., Klagsbrun, M., and Bernfieldt, M., Cell Biol., 1994, vol. 91, no. 23, pp. 11035–11039.

    CAS  Google Scholar 

  11. Il'yashenko, M.G., Tarasova, G.N., and Guseva, A.I., Sovrem. Probl. Nauki Obrazov., 2012, no. 2, pp. 1–9.

    Google Scholar 

  12. Turner, J., Cho, Y., Dinh, N., Alan, J., Lehrer, R.I., and Waring, A.J., Antimicrob. Agents Chemother., 1998, vol. 42, no. 9, pp. 2206–2214.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Wiesner, J. and Vilcinskas, A., Virulence, 2010, vol. 1, no. 5, pp. 440–464.

    Article  PubMed  Google Scholar 

  14. De Smet, K. and Contreras, R., Biotechnol. Lett., 2005, vol. 27, no. 18, pp. 1337–1347.

    Article  PubMed  CAS  Google Scholar 

  15. Lai, Y. and Gallo, R.L., Trends Immunol., 2009, vol. 30, no. 3, pp. 131–141.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Azimova, V.T., Potaturkina-Nesterova, N.I., and Nesterov, A.S., Sovrem. Probl. Nauki Obrazov., 2015, no. 1–1, pp. 1–8.

    Google Scholar 

  17. Mai, S., Mauger, M.T., Niu, L.-N., Barnes, J.B., Kao, S., Bergeron, B.E., Ling, J.-Q., and Tay, F.R., Acta Biomater., 2017, vol. 49, no. 1, pp. 16–35.

    Article  PubMed  CAS  Google Scholar 

  18. Rothstein, D.M., Spacciapoli, P., Tran, L.T., Xu, T., Roberts, F.D., Dalla, SerraM., Buxton, D.K., Oppenheim, F.G., and Friden, P., Antimicrob. Agents Chemother., 2001, vol. 45, no. 5, pp. 1367–1373.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Mishra, S., Ahirwar, D.K., and Ganju, R.K., Br. J. Dermatol., 2016, vol. 175, no. 6, pp. 1141–1142.

    Article  PubMed  CAS  Google Scholar 

  20. Gläser, R., Harder, J., Lange, H., Bartels, J., Christophers, E., and Schröder, J.-M., Nat. Immunol., 2005, vol. 6, no. 1, pp. 57–64.

    Article  PubMed  CAS  Google Scholar 

  21. Abtin, A., Eckhart, L., Gläser, R., Gmeiner, R., Mildner, M., and Tschachler, E., J. Invest. Dermatol., 2010, vol. 130, no. 10, pp. 2423–2430.

    Article  PubMed  CAS  Google Scholar 

  22. Broome, A.-M., Ryan, D., and Eckert, R.L., J. Histochem. Cytochem., 2003, vol. 51, no. 5, pp. 675–685.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  23. Thorey, I.S., Roth, J., Regenbogen, J., Halle, J.P., Bittner, M., Vogl, T., Kaesler, S., Bugnon, P., and Reitmaier, B., J. Biol. Chem., 2001, vol. 276, no. 38, pp. 35818–35825.

    Article  PubMed  CAS  Google Scholar 

  24. Niyonsaba, F., Kiatsurayanon, C., Chieosilapatham, P., and Ogawa, H., Exp. Dermatol., 2017, vol. 26, no. 11, pp. 989–998.

    Article  PubMed  CAS  Google Scholar 

  25. Koten, B., Simanski, M., Glaser, R., Podschun, R., Schroder, J.M., and Harder, J., PLoS One, 2009, vol. 4, no. 7. e6424.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Reithmayer, K., Meyer, K.C., Kleditzsch, P., Tiede, S., Uppalapati, S.K., Gläser, R., Harder, J., Schröder, J.M., and Paus, R., Br. J. Dermatol., 2009, vol. 161, no. 1, pp. 78–89.

    Article  PubMed  CAS  Google Scholar 

  27. Brogden, K.A., Nat. Rev. Microbiol., 2005, vol. 3, no. 3, pp. 238–250.

    Article  PubMed  CAS  Google Scholar 

  28. Kavanagh, K. and Dowd, S., J. Pharm. Pharmacol., 2004, vol. 56, no. 3, pp. 285–289.

    Article  PubMed  CAS  Google Scholar 

  29. Mochon, A.B. and Liu, H., PLoS Pathog., 2008, vol. 4, no. 10. e1000190.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  30. DaVeiga, S.P., Allergy Asthma Proc., 2012, vol. 33, no. 3, pp. 227–234.

    Article  PubMed  Google Scholar 

  31. Ong, P.Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R.L., and Leung, D.Y.M., N. Engl. J. Med., 2002, vol. 347, no. 15, pp. 1151–1160.

    Article  PubMed  CAS  Google Scholar 

  32. Nomura, I., Goleva, E., Howell, M.D., Hamid, Q.A., Ong, P.Y., Hall, C.F., Darst, M.A., Gao, B., and Boguniewicz, M., J. Immunol., 2003, vol. 171, no. 6, pp. 3262–3269.

    Article  PubMed  CAS  Google Scholar 

  33. Kanda, N. and Watanabe, S., Immunobiology, 2012, vol. 217, no. 4, pp. 436–445.

    Article  PubMed  CAS  Google Scholar 

  34. Nestle, F.O., Kaplan, D.H., and Barker, J., Psoriasis, N. Engl. J. Med., 2009, vol. 361, pp. 496–509.

    Article  CAS  Google Scholar 

  35. Smithrithee, R., Niyonsaba, F., Kiatsurayanon, C., Ushio, H., Ikeda, S., Okumura, K., and Ogawa, H., J. Dermatol. Sci., 2015, vol. 77, no. 1, pp. 46–53.

    Article  PubMed  CAS  Google Scholar 

  36. Morizane, S., Yamasaki, K., Mühleisen, B., Kotol., P.F., Murakami, M., Aoyama, Y., Iwatsuki, K., Hata, T., and Gallo, R.L., J. Invest. Dermatol., 2012, vol. 132, no. 1, pp. 135–143.

    Article  PubMed  CAS  Google Scholar 

  37. Kerkhoff, C., Voss, A., Scholzen, T.E., Averill, M.M., Zänker, K.S., and Bornfeldt, K.E., Exp. Dermatol., 2012, vol. 21, no. 11, pp. 822–826.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  38. Hollox, E.J., Cytogenet. Genome Res., 2009, vol. 123, nos. 1–4, pp. 148–155.

    CAS  Google Scholar 

  39. Koczulla, R., Degenfeld, G. Von Kupatt, C., Krötz, F., Zahler, S., Gloe, T., Issbrücker, K., Unterberger, P., and Zaiou, M., J. Clin. Invest., 2003, vol. 111, no. 11, pp. 1665–1672.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  40. Niyonsaba, F., Nagaoka, I., Ogawa, H., and Okumura, K., Curr. Pharm. Des., 2009, vol. 15, no. 21, pp. 2393–2413.

    Article  PubMed  CAS  Google Scholar 

  41. Niyonsaba, F., Ushio, H., Nakano, N., Ng, W., Sayama, K., Hashimoto, K., Nagaoka, I., Okumura, K., and Ogawa, H., J. Invest. Dermatol., 2007, vol. 127, no. 3, pp. 594–604.

    Article  PubMed  CAS  Google Scholar 

  42. Schwab, V.D., Sulk, M., Seeliger, S., Nowak, P., Aubert, J., Mess, C., Rivier, M., Carlavan, I., and Rossio, P., J. Invest. Dermatol. Symp. Proc., 2011, vol. 15, no. 1, pp. 53–62.

    Article  CAS  Google Scholar 

  43. Yamasaki, K., Di Nardo, A., Bardan, A., Murakami, M., Ohtake, T., Coda, A., Dorschner, R.A., Bonnart, C., and Descargues, P., Nat. Med., 2007, vol. 13, no. 8, pp. 975–980.

    Article  PubMed  CAS  Google Scholar 

  44. Melnik, B.C., Exp. Dermatol., 2014, vol. 23, no. 12, pp. 868–873.

    Article  PubMed  CAS  Google Scholar 

  45. Schauber, J. and Gallo, R.L., Exp. Dermatol., 2008, vol. 17, no. 8, pp. 633–639.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  46. Kreuter, A., Hyun, J., Stücker, M., Sommer, A., Altmeyer, P., and Gambichler, T., J. Am. Acad. Dermatol., 2006, vol. 54, no. 3, pp. 440–447.

    Article  PubMed  Google Scholar 

  47. Takahashi, T., Asano, Y., Nakamura, K., Yamashita, T., Saigusa, R., Ichimura, Y., Toyama, T., Taniguchi, T., and Yoshizaki, A., Br. J. Dermatol., 2016, vol. 175, no. 6, pp. 1195–1203.

    Article  PubMed  CAS  Google Scholar 

  48. Giusti, L., Bazzichi, L., Baldini, C., Ciregia, F., Mascia, G., Rosso, M.Del., Bombardieri, S., and Lucacchini, A., J. Rheumatol., 2007, vol. 34, no. 10, pp. 2063–2069.

    CAS  Google Scholar 

  49. Shanmugam, V.K., Price, P., Attinger, C.E., and Steen, V.D., Int. J. Rheumatol., 2010, vol. 2010, no. 1, pp. 1–8.

    Google Scholar 

  50. Economopoulou, M., Bdeir, K., Cines, D.B., Fogt, F., Bdeir, Y., Lubkowski, J., Lu, W., Preissner, K.T., Hammes, H.P., and Chavakis, T., Blood, 2005, vol. 106, no. 12, pp. 3831–3838.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  51. Ardoin, S.P. and Pisetsky, D.S., Arthritis Res. Ther., 2008, vol. 10, no. 5, p. 218.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  52. Nagaoka, I., Tamura, H., and Hirata, M., J. Immunol., 2006, vol. 176, no. 5, pp. 3044–3052.

    Article  PubMed  CAS  Google Scholar 

  53. Lande, R., Ganguly, D., Facchinetti, V., Frasca, L., Conrad, C., Gregorio, J., Meller, S., Chamilos, G., and Sebasigari, R., Sci. Transl. Med., 2011, vol. 3, no. 73, p. 73.

    Article  Google Scholar 

  54. Coretti, L., Natale, A., Cuomo, M., Florio, E., Keller, S., Lembo, F., Chiariotti, L., and Pero, R., Mediators Inflamm., 2017, vol. 2017, no. 1, pp. 1–8.

    Article  CAS  Google Scholar 

  55. Tufan, A., Mercan, R., Pasaoglu, O.T., Pasaoglu, H., Ozturk, M.A., Goker, B., and Haznedaroglu, S., Peptides, 2014, vol. 57, no. 1, pp. 17–19.

    Article  PubMed  CAS  Google Scholar 

  56. Guttsches, A.-K., Jacobsen, F., Theiss, C., Rittig, A., Rehimi, R., Kley, R.A., Vorgerd, M., and Steinstraesser, L., Innate Immun., 2014, vol. 20, no. 1, pp. 49–60.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia

    M. V. Konovalova, G. V. Lutsenko & E. V. Svirshchevskaya

  2. Fundamentals of Biotechnology Institute of Bioengineering, Federal Research Center, Russian Academy of Sciences, Moscow, 119071, Russia

    A. A. Zubareva

Authors
  1. M. V. Konovalova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Zubareva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. V. Lutsenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. V. Svirshchevskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. V. Konovalova.

Additional information

Original Russian Text © M.V. Konovalova, A.A. Zubareva, G.V. Lutsenko, E.V. Svirshchevskaya, 2018, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2018, Vol. 54, No. 3, pp. 236–243.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Konovalova, M.V., Zubareva, A.A., Lutsenko, G.V. et al. Antimicrobial Peptides in Health and Disease (Review). Appl Biochem Microbiol 54, 238–244 (2018). https://doi.org/10.1134/S0003683818030079

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0003683818030079

Keywords

Search

Navigation