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Immunobiological properties of new unencapsulated Bacillus anthracis 363/11 strain

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Abstract

The results of a study on the immunobiological properties of a new, naturally attenuated, unencapsulated Bacillus anthracis 363/11 strain in comparison with the properties of the anthrax vaccine strain 55-VNIIVVIM, which is currently used in Russia and post-Soviet states, are presented in the article. Some differences in the phenotypes of the aforementioned strains are shown. The new strain caused lysis of sheep erythrocytes by α- but not by β-type; the strain had many more active proteinases and synthesized protocatechuic acid (PCA), in contrast to the vaccine strain. It was ascertained that immunization of animals by the new strain protects them from death after infection by field isolates of B. anthracis, while the 55-VNIIVVIM strain does not create this immunity. The data indicate that the new strain can be used to develop and improve anthrax prevention.

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Abbreviations

ImD50 :

immunizing dose for 50% animals

LD50 :

lethal dose for 50% animals

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Authors and Affiliations

  1. National Research Institute for Veterinary Virology and Microbiology (NRIVVaM Russian Academy of Agricultural Sciences), Volginsky, Vladimir region, 601125, Russia

    I. Yu. Egorova, T. A. Sevskii & Yu. O. Selyaninov

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  1. I. Yu. Egorova
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  2. T. A. Sevskii
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  3. Yu. O. Selyaninov
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Correspondence to I. Yu. Egorova.

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Original Russian Text © I.Yu. Egorova, T.A. Sevskii, Yu.O. Selyaninov, 2015, published in Biotekhnologiya, 2015, No. 5, pp. 34–40.

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Egorova, I.Y., Sevskii, T.A. & Selyaninov, Y.O. Immunobiological properties of new unencapsulated Bacillus anthracis 363/11 strain. Appl Biochem Microbiol 52, 733–738 (2016). https://doi.org/10.1134/S0003683816080044

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