Skip to main content

Advertisement

Log in

Determination of residual protein and endotoxins in chitosan (review)

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

Methods for the determination of residual protein and endotoxins in chitosan preparations, which can be used as vectors for biologically active compounds delivery, are discussed. The limits of their use for the determination of residual impurities in chitosan preparations associated with the structure of the biopolymer are estimated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Cheung, R.C.F., Ng, T.B., Wong, J.H., and Cha, W.Y., Mar. Drugs, 2015, vol. 13, no. 8, pp. 5156–5186.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Diaz-Rojas, E.I., Arguelles-Monal, W.M., Higuera-Ciapara, I., Hernandez, J., Lizardi-mendoza, J., and Goycoolea, F.M., Macromol. Biosci., 2006, vol. 6, no. 5, pp. 340–347.

    Article  CAS  PubMed  Google Scholar 

  3. Fernandez-Pan, I., Mate, J.I., Gardrat, C., and Coma, V., Food Hydrocolloids, 2015, vol. 51, no. 1, pp. 60–68.

    Article  CAS  Google Scholar 

  4. Khitozan (Chitosan), Skryabin, K.G., Mikhailov, S.N., and Varlamov, V.P., Eds., Moscow Tsentr “Bioinzheneriya” RAN, 2013.

  5. Ngo, D.H., Vo, T.S., Ngo, D.N., Kang, K.H., Je, J.Y., Pham, H.N.D., Byun, H.G., and Kim, S.K., Food Hydrocolloids, 2015, vol. 51, no. 1, pp. 200–216.

    Article  CAS  Google Scholar 

  6. Badwan, A.A., Rashid, I., Al Omari, M.H., and Darras, F.H., Mar. Drugs, 2015, vol. 13, no. 3, pp. 1519–1547.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kyzas, G.Z. and Bikiaris, D.N., Mar. Drugs, 2015, vol. 13, no. 1, pp. 312–337.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Younes, I. and Rinaudo, M., Mar. Drugs, 2015, vol. 13, no. 3, pp. 1133–1174.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chien, R.C., Yen, M.T., and Mau, J.L., Carbohydr. Res., 2016, vol. 138, no. 1, pp. 259–264.

    Article  CAS  Google Scholar 

  10. Shagdarova, B.Ts., Il’ina, A.V., and Varlamov, V.P., Appl. Biochem. Microbiol., 2016, vol. 52, no. 2, pp. 222–225.

    Article  CAS  Google Scholar 

  11. Ghendon, Y., Markushin, S., Vasiliev, Y., Akopova, I., Koptiaeva, I., Krivtsov, G., Borisova, O., Ahmatova, N., Kurbatova, E., Mazurina, S., and Gervazieva, V., J. Med. Virol., 2009, vol. 81, no. 3, pp. 494–506.

    Article  CAS  PubMed  Google Scholar 

  12. Szymanska, E. and Winnicka, K., Mar. Drugs, 2015, vol. 13, no. 4, pp. 1819–1846.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Alvarez, F.J., Molecules, 2014, vol. 19, no. 4, pp. 4433–4451.

    Article  PubMed  Google Scholar 

  14. Dzung, N.A., Ha, N.T.N., Van, D.T.H., Phuong, N.T.L., Quynh, N.T.N., Hiep, D.M., and Hiep, L.V., World Acad. Sci. Eng. Technol., 2011, vol. 5, no. 1, pp. 12–22.

    Google Scholar 

  15. Aranaz, I., Mengibar, M., Harris, R., Panos, I., Miralles, B., Acosta, N., Galed, G., and Heras, A., Current Chem. Biol., 2009, vol. 3, no. 2, pp. 203–230.

    CAS  Google Scholar 

  16. Buske, S., Young, K., Weber, B., Rades, T., and Hook, S., Vaccine, 2013, vol. 31, no. 42, pp. 4812–4819.

    Article  PubMed  Google Scholar 

  17. Li, B., Zhang, J., Dai, F., and Xia, W., Carbohydr. Res., 2012, vol. 88, no. 1, pp. 206–212.

    Article  CAS  Google Scholar 

  18. Gosudarstvennaya farmakopeya Rossiiskoi Federatsii (State Pharmacopoeia of the Russian Federation), Moscow: Nauchnyi tsentr ekspertizy sredstv meditsinskogo primeneniya, 2008, vol. XII, pt. 1.

  19. Stoschech, C.M., Methods Enzymol., 1990, vol. 182, no. 1, pp. 50–68.

    Article  Google Scholar 

  20. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J., J. Biol. Chem., 1951, vol. 193, no. 1, pp. 265–275.

    CAS  PubMed  Google Scholar 

  21. Waffenschmidt, S. and Jaenicke, L., Anal. Biochem., 1987, vol. 165, no. 2, pp. 337–340.

    Article  CAS  PubMed  Google Scholar 

  22. Bradford, M.M., Anal. Biochem., 1976, vol. 72, nos. 1–2, pp. 248–254.

    Article  CAS  PubMed  Google Scholar 

  23. Chatterjee, S., Adhya, M., Guha, A.K., and Chatterjee, B.P., Proc. Biochem., 2004, vol. 40, no. 1, pp. 395–400.

    Article  Google Scholar 

  24. Gartman, O.R. and Vorob’eva, V.M., Fundam. Issled. Farmatsevt. Nauki, 2013, no. 6, pp. 1188–1192.

    Google Scholar 

  25. Loginova, O.O., Kholyavka, M.G., Artyukhov, V.G., and Belenova, A.S., Vestnik VGU, Ser. Khim. Biol. Farmats., 2013, no. 2, pp. 116–119.

    Google Scholar 

  26. Sandeep, A., Sangameshwar, K., Mukesh, G., Chandrakant, R., and Avinash, D., Indo Am. J. Pharm. Res., 2013, vol. 13, no. 12, pp. p. 1564–1574.

    Google Scholar 

  27. Gogichaeva, N.V., Williams, T., and Alterman, M.A., J. Am. Soc. Mass Spectrom., 2007, vol. 18, no. 2, pp. 279–284.

    Article  CAS  PubMed  Google Scholar 

  28. Magalhães, P.O., Lopes, A.M., Mazzola, P.G., Rangel-Yagui, C., Penna, T.C.V., and Pessoa, A., J. Pharm. Pharmaceut. Sci., 2007, vol. 10, no. 3, pp. 388–404.

    Google Scholar 

  29. Morita, T., Tanaka, S., Nakamura, T., and Iwanaga, S., FEBS Lett., 1981, vol. 129, no. 2, pp. 318–321.

    Article  CAS  Google Scholar 

  30. Mikami, T., Nagasa, T., Matsumoto, T., Suzuki, S., and Suzuki, M., Microbiol. Immunol., 1982, vol. 26, no. 5, pp. 403–409.

    Article  CAS  PubMed  Google Scholar 

  31. Nolte, A., Hossfeld, S., Post, M., Niederlaender, J., Walker, T., Schlensak, C., and Wendel, H.P., J. Mater. Sci.: Mater. Med., 2014, vol. 25, no. 5, pp. 2121–2130.

    CAS  Google Scholar 

  32. Hemker, H.C., Dieri, R.A., De Smedt, E., and Beguin, S., Thromb. Haemost., 2006, vol. 96, no. 5, pp. 553–561.

    CAS  PubMed  Google Scholar 

  33. Daneshian, M., Guenther, A., Wendel, A., Hartung, T., and von Aulock, S., J. Immunol. Methods, 2006, vol. 313, nos. 1–2, pp. 169–175.

    Article  CAS  PubMed  Google Scholar 

  34. Mazzotti, F., Beuttler, J., Zeller, R., Fink, U., Schindler, S., Wendel, A., Hartung, T., and von Aulock, S., J. Biomed. Mater. Res. A, 2007, vol. 80, no. 2, pp. 276–282.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to V. P. Varlamov.

Additional information

Original Russian Text © A.V. Il’ina, V.P. Varlamov, 2016, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2016, Vol. 52, No. 5, pp. 455–459.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Il’ina, A.V., Varlamov, V.P. Determination of residual protein and endotoxins in chitosan (review). Appl Biochem Microbiol 52, 471–475 (2016). https://doi.org/10.1134/S0003683816050082

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0003683816050082

Keywords