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Production of taunit–antibiotic nanocomplexes and study of their antifungal activity relative to Aspergillus niger and Candida albicans

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Abstract

Nanocomplexes based on a modern Taunit nanosorbent with polyene antibiotics (amphotericin B, nystatin A1, and natamycin) widely used in medical practice were obtained for the first time; their antifungal activity was studied. It was demonstrated that the Taunit–nystatin A1 complex is active as compared to Aspergillus niger, while the Taunit–natamycin complex is active as compared to Aspergillus niger and Candida albicans. The Taunit–amphotericin B nanocomplex is not active relative to the studied test organisms (A. niger and C. albicans). Possible mechanisms of the action of the obtained complexes are discussed.

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Abbreviations

DMSO:

dimethyl sulfoxide

CFU:

colony-forming unit

MCNT:

multilayer carbon nanotubes

MRSA:

meticillinresistant Staphylococcus aureus

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Authors and Affiliations

  1. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119991, Russia

    A. V. Timofeeva & L. A. Baratova

  2. Mendeleyev University of Chemical Technology of Russia, Moscow, 125047, Russia

    M. V. Ilyina

  3. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow, 119021, Russia

    E. A. Stepashkina & G. S. Katrukha

Authors
  1. A. V. Timofeeva
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  2. M. V. Ilyina
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  3. E. A. Stepashkina
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  4. L. A. Baratova
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  5. G. S. Katrukha
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Correspondence to A. V. Timofeeva.

Additional information

Original Russian Text © A.V. Timofeeva, M.V. Ilyina, E.A. Stepashkina, L.A. Baratova, G.S. Katrukha, 2014, published in Biotekhnologiya, 2014, No. 3, pp. 18–23.

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Timofeeva, A.V., Ilyina, M.V., Stepashkina, E.A. et al. Production of taunit–antibiotic nanocomplexes and study of their antifungal activity relative to Aspergillus niger and Candida albicans . Appl Biochem Microbiol 51, 887–892 (2015). https://doi.org/10.1134/S0003683815090070

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  • DOI: https://doi.org/10.1134/S0003683815090070

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