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Biologically active peptides isolated from dill Anethum graveolens L.

Applied Biochemistry and Microbiology volume 51, pages 362–366 (2015)Cite this article

Abstract

Peptide mixtures with molecular weights of 1000–2000 Da and in vivo membrano-trophic activity against mouse hepatocyte culture at very low concentrations were isolated from dill Anethum graveolens L. leaves. It has been found that plant peptides in aqueous solution formed larger nanosized particles of approximately 90 nm with a secondary structure mainly composed of β-structures and random coil structures. We demonstrated that peptides isolated from A. graveolens in vitro at an ultra-low dosage affected the size of the area of pigmented cells of amphibian liver, which are analogous to Kupffer cells of the mammalian liver, using roller organotypic newt liver culture models.

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Authors and Affiliations

  1. A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences, Moscow, 119991, Russia

    O. G. Kulikova, D. I. Mal’tsev, A. P. Il’ina & A. V. Burdina

  2. N.K. Koltsov Institute of Developmental Biology Russian Academy of Sciences, Moscow, 119334, Russia

    V. P. Yamskova & I. A. Yamskov

Authors
  1. O. G. Kulikova
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  2. D. I. Mal’tsev
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  3. A. P. Il’ina
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  4. A. V. Burdina
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  5. V. P. Yamskova
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  6. I. A. Yamskov
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Corresponding author

Correspondence to O. G. Kulikova.

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Original Russian Text © O.G. Kulikova, D.I. Mal’tsev, A.P. Il’ina, A.V. Burdina, V.P. Yamskova, I.A. Yamskov, 2015, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2015, Vol. 51, No. 3, pp. 348–353.

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Kulikova, O.G., Mal’tsev, D.I., Il’ina, A.P. et al. Biologically active peptides isolated from dill Anethum graveolens L.. Appl Biochem Microbiol 51, 362–366 (2015). https://doi.org/10.1134/S0003683815030114

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  • DOI: https://doi.org/10.1134/S0003683815030114

Keywords

  • plants
  • peptides
  • cultivation
  • liver protection