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The effects of alkylhydroxybenzenes on homoserine lactone-induced manifestations of quorum sensing in bacteria

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Abstract

The effects of four alkylhydroxybenzene (AHB) homologs with different hydrocarbon chain lengths on the synthesis of violacein pigment induced by C6-homoserine lactone (HSL) and biofilm formation by Chromobacterium violaceum NCTC 13274 and on Escherichia coli pAL103 bioluminescence in the presence of C6-oxo-HSL were studied. Alkylhydroxybenzenes inhibit the growth of C. violaceum increased in the C5-AHB → C12-AHB series in the absence of this activity in C1-AHB. Subinhibitory AHB concentrations reduced violacein production and suppressed biofilm formation. These effects were presented as individual and group regression dependencies between the analysed parameters. Using the bioluminescent model, the regulatory effects of AHBs were not associated with their direct competition with HSL and that they develop as a result of changes in the sensitivity of bacterial cells to the respective quorum sensing inducer.

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Authors and Affiliations

  1. Orenburg State University, pr. Pobedy 13, Orenburg, 460018, Russia

    D. G. Deryabin, A. A. Kamayeva & A. A. Tolmacheva

  2. Vinogradsky Institute of Microbiology, Russian Academy of Sciences, pr. Shestidesyatiletiya Oktyabrya 7, Moscow, 117312, Russia

    G. I. El-Registan

Authors
  1. D. G. Deryabin
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  2. A. A. Kamayeva
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  3. A. A. Tolmacheva
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  4. G. I. El-Registan
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Correspondence to D. G. Deryabin.

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Original Russian Text © D.G. Deryabin, A.A. Kamayeva, A.A. Tolmacheva, G.I. El-Registan, 2014, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2014, Vol. 50, No. 4, pp. 391–397.

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Deryabin, D.G., Kamayeva, A.A., Tolmacheva, A.A. et al. The effects of alkylhydroxybenzenes on homoserine lactone-induced manifestations of quorum sensing in bacteria. Appl Biochem Microbiol 50, 353–358 (2014). https://doi.org/10.1134/S0003683814040036

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