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Novel antiproteinase hemosorbent

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Abstract

A method has been developed for producing a biospecific hydrogel hemosorbent by the radical copolymerization of an unsaturated derivative of ovomucoid from duck egg white with acrylamide and N, N’-methylene bisacrylamide in an aqueous solution in the presence of mercaptoacetic acid serving as a chain transfer agent. The use of a chain transfer agent has been shown to result in changes in the structure of the hydrogel formed, namely, an increase in the degree of swelling in aqueous solutions and a decrease in the number of large pores. This creates favorable conditions for the functioning of immobilized ovomucoid and allows for an increase in the serine proteinase absorption capacity of the hemosorbent.

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Authors and Affiliations

  1. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia

    T. A. Valueva

  2. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991, Russia

    I. L. Valuev, L. V. Vanchugova & L. I. Valuev

Authors
  1. T. A. Valueva
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  2. I. L. Valuev
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  3. L. V. Vanchugova
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  4. L. I. Valuev
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Additional information

Original Russian Text © T.A. Valueva, I.L. Valuev, L.V. Vanchugova, L.I. Valuev, 2014, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2014, Vol. 50, No. 1, pp. 108–111.

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Valueva, T.A., Valuev, I.L., Vanchugova, L.V. et al. Novel antiproteinase hemosorbent. Appl Biochem Microbiol 50, 94–97 (2014). https://doi.org/10.1134/S0003683814010116

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  • DOI: https://doi.org/10.1134/S0003683814010116

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